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Changes in Early-Onset Group B Beta Hemolytic Streptococcus Disease With Changing Recommendations For Prophylaxis

Journal of Perinatology volume 22, pages 516–522 (2002)Cite this article

Abstract

OBJECTIVE: To determine the incidence of early-onset group B beta hemolytic streptococcal (EOGBS) infection and the association between changes in the incidence and intrapartum antibiotic prophylaxis (IAP).

STUDY DESIGN: A retrospective population survey of infants with GBS at <7 days of age with a nested case–control study of non-GBS infants over the same time period, January 1985 to December 1998. The incidence of GBS and maternal antibiotic treatment during labor was analyzed as a function of time period: prior to publication of guidelines for prevention of EOGBS (1985–1992), following AAP/ACOG guidelines (1993–1995), and following CDC consensus guidelines (1996–1998).

RESULTS: Fifty-six cases of EOGBS infection occurred among 53,088 live births. The incidence declined from 1.5/1000 before any guidelines to 0.67/1000 after AAP/ACOG guidelines (p=0.004), and continued to decline after the CDC consensus statement (0.28/1000) (p=0.38). IAP remained stable (33% of at risk mothers) until after introduction of the CDC consensus guidelines (59%, p=0.02).

CONCLUSION: IAP did not fully explain the decline in EOGBS incidence in our center.

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Author notes

  1. Imelda P Uy MD

    Present address: Pediatrix Medical Group of South Carolina, Spartanburg Regional Medical Center, 101 East Wood Street, Spartanburg, 29303, SC, USA

Authors and Affiliations

  1. Department of Pediatrics, Division of Neonatology, Golisano Children's Hospital at Strong, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA

    Imelda P Uy MD, Carl T D'Angio MD & Ronnie Guillet MD, PhD

  2. Department of Microbiology, Golisano Children's Hospital at Strong, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA

    Marilyn Menegus PhD

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Uy, I., D'Angio, C., Menegus, M. et al. Changes in Early-Onset Group B Beta Hemolytic Streptococcus Disease With Changing Recommendations For Prophylaxis. J Perinatol 22, 516–522 (2002). https://doi.org/10.1038/sj.jp.7210798

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