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Risk of Cranial Ultrasound Abnormalities in Very-low-birth-weight Infants Conceived With Assisted Reproductive Techniques

Journal of Perinatology volume 22, pages 37–45 (2002)Cite this article

Abstract

OBJECTIVE: To evaluate risks of cranial ultrasound abnormalities among very-low-birth-weight (VLBW) infants conceived with fertility therapy (ovulation induction only or with assisted reproductive techniques [ART]) and of multiple gestation pregnancies.

STUDY DESIGN: The incidences of cranial ultrasound abnormalities in 1473 VLBW infants conceived with and without fertility therapy and born of multiple versus singleton pregnancies were compared, using logistic regression models.

RESULTS: Infants conceived with ART were less likely to have intraventricular hemorrhage (IVH). Twins and triplets had risks of cranial ultrasound abnormalities similar to those of singletons. Twins and triplets conceived with ART were at lower risk of IVH.

CONCLUSION: VLBW infants conceived with ART do not appear to be at increased risk of cranial ultrasound abnormalities. Likewise, twins and triplets were not at increased risk of these abnormalities.

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Authors and Affiliations

  1. Beth Israel Deaconess Medical Center, Boston, MA, USA

    Jane E Stewart MD & Jodi Abbott MD

  2. Children's Hospital, Boston, MA, USA

    Jane E Stewart MD, Elizabeth N Allred MS, Alan Leviton MD, Olaf Dammann MD & Marcello Pagano PhD

  3. Harvard Medical School, Boston, MA, USA

    Jane E Stewart MD, Elizabeth N Allred MS, Alan Leviton MD, Linda J Van Marter MD, David Genest MD & Olaf Dammann MD

  4. Harvard School of Public Health, Boston, MA, USA

    Elizabeth N Allred MS & Marcello Pagano PhD

  5. Children's Hospital Medical Center, Cincinnati, OH, USA

    Margaret Collins MD

  6. University of Cincinnati School of Medicine, Cincinnati, OH, USA

    Margaret Collins MD

  7. Michigan State University, East Lansing, MI, USA

    Nigel Paneth MD

  8. Bellevue Research Foundation, Niskayuna, NY, USA

    M Lynne Reuss MD

  9. Columbia University, New York, NY, USA

    M Lynne Reuss MD, Mervyn Susser MB, Ulana Sanocka MD, Farrokh Shahrivar MD, Petra Banogan MD & Debra Heller MD

  10. St. Peter's Medical Center, New Brunswick, NJ, USA

    Thomas Hegyi MD, Mark Hiatt MD & Susan Shen-Schwarz MD

  11. Robert Wood Johnson Medical School, Princeton, NJ, USA

    Thomas Hegyi MD, Mark Hiatt MD & Susan Shen-Schwarz MD

  12. Babies' Hospital, New York, NY, USA

    Ulana Sanocka MD & Debra Heller MD

  13. St. Luke's-Roosevelt Medical Center, New York, NY, USA

    Farrokh Shahrivar MD & Petra Banogan MD

  14. Brigham and Women's Hospital, Boston, MA, USA

    Linda J Van Marter MD & David Genest MD

  15. New England Medical Center, Boston, MA, USA

    Karl C K Kuban MD

  16. Tufts University School of Medicine, Boston, MA, USA

    Karl C K Kuban MD

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  1. Jane E Stewart MD
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Stewart, J., Allred, E., Collins, M. et al. Risk of Cranial Ultrasound Abnormalities in Very-low-birth-weight Infants Conceived With Assisted Reproductive Techniques. J Perinatol 22, 37–45 (2002). https://doi.org/10.1038/sj.jp.7210666

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