Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Alternative Metalloporphyrins for the Treatment of Neonatal Jaundice

Journal of Perinatology volume 21, pages S108–S113 (2001)Cite this article

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Yao TC, Stevenson DK Advances in the diagnosis and treatment of neonatal hyperbilirubinemia Clin Perinatol 1995 22 741–58

    Article  CAS  Google Scholar 

  2. Dennery PA, Seidman DS, Stevenson DK Neonatal hyperbilirubinemia: Pathophysiology, prevention, and treatment N Engl J Med 2001 344 581–90

    Article  CAS  Google Scholar 

  3. Stevenson DK, Rodgers PA, Vreman HJ The use of metalloporphyrins for the chemoprevention of neonatal jaundice Am J Dis Child 1989 143 353–6

    CAS  PubMed  Google Scholar 

  4. Vreman HJ, Verter J, Oh W, et al Interlaboratory variability of bilirubin measurements Clin Chem 1996 42 869–73

    CAS  PubMed  Google Scholar 

  5. Vreman HJ, Mahoney JJ, Stevenson DK Carbon monoxide and carboxyhemoglobin Adv Pediatr 1995 42 303–25

    CAS  PubMed  Google Scholar 

  6. Vreman HJ, Wong RJ, Stevenson DK Carbon monoxide in breath, blood, and other tissues In: Penney DG, editor. Carbon Monoxide Toxicity Boca Raton, FL: CRC Press 2000 p. 19–60

    Chapter  Google Scholar 

  7. Bhutani VK, Gourley GR, Adler S, Kreamer B, Dalin C, Johnson LH Noninvasive measurement of total serum bilirubin in a multiracial predischarge newborn population to assess the risk of severe hyperbilirubinemia Pediatrics 2000 106 E17

    Article  CAS  Google Scholar 

  8. Tenhunen R, Marver HS, Schmid R The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase Proc Natl Acad Sci USA 1968 61 748–55

    Article  CAS  Google Scholar 

  9. Maines MD Zinc protoporphyrin is a selective inhibitor of heme oxygenase activity in the neonatal rat Biochim Biophys Acta 1981 673 339–50

    Article  CAS  Google Scholar 

  10. Marks GS, Brien JF, Nakatsu K, McLaughlin BE Does carbon monoxide have a physiological function? Trends Pharmacol Sci 1991 12 185–8

    Article  CAS  Google Scholar 

  11. Appleton SD, Chretien ML, McLaughlin BE, et al Selective inhibition of heme oxygenase, without inhibition of nitric oxide synthase or soluble guanylyl cyclase, by metalloporphyrins at low concentrations Drug Metab Dispos 1999 27 1214–9

    CAS  PubMed  Google Scholar 

  12. Wong RJ, Vreman HJ, Stevenson DK (Metallo)porphyrin inhibitors of heme oxygenase also inhibit lipid peroxidation (LP) Pediatr Res 2000 47 465

    Google Scholar 

  13. Maines MD Heme oxygenase: Clinical Applications and Functions Boca Raton, FL: CRC Press 1992

    Google Scholar 

  14. Maines MD Heme oxygenase: Function, multiplicity, regulatory mechanisms, and clinical applications FASEB J 1988 2 2557–68

    Article  CAS  Google Scholar 

  15. Drummond GS, Galbraith RA, Sardana MK, Kappas A Reduction of the C2 and C4 vinyl groups of Sn-protoporphyrin to form Sn-mesoporphyrin markedly enhances the ability of the metalloporphyrin to inhibit in vivo heme catabolism Arch Biochem Biophys 1987 255 64–74

    Article  CAS  Google Scholar 

  16. Valaes T, Petmezaki S, Henschke C, Drummond GS, Kappas A Control of jaundice in preterm newborns by an inhibitor of bilirubin production: Studies with tin-mesoporphyrin Pediatrics 1994 93 1–11

    CAS  Google Scholar 

  17. Martinez JC, Garcia HO, Otheguy LE, Drummond GS, Kappas A Control of severe hyperbilirubinemia in full-term newborns with the inhibitor of bilirubin production Sn-mesoporphyrin Pediatrics 1999 103 1–5

    Article  CAS  Google Scholar 

  18. Labbé RF, Vreman HJ, Stevenson DK Zinc protoporphyrin: A metabolite with a mission Clin Chem 1999 45 2060–72

    PubMed  Google Scholar 

  19. Chernick RJ, Martasek P, Levere RD, Margreiter R, Abraham NG Sensitivity of human tissue heme oxygenase to a new synthetic metalloporphyrin Hepatology 1989 10 365–9

    Article  CAS  Google Scholar 

  20. Vreman HJ, Lee OK, Stevenson DK In vitro and in vivo characteristics of a heme oxygenase inhibitor: ZnBG Am J Med Sci 1991 302 335–41

    Article  CAS  Google Scholar 

  21. Vallier HA, Rodgers PA, Stevenson DK Inhibition of heme oxygenase after oral vs intraperitoneal administration of chromium porphyrins Life Sci 1993 52 L79–84

    Article  Google Scholar 

  22. Vreman HJ, Cipkala DA, Stevenson DK Characterization of porphyrin heme oxygenase inhibitors Can J Physiol Pharmacol 1996 74 278–85

    CAS  PubMed  Google Scholar 

  23. Vreman HJ, Ekstrand BC, Stevenson DK Selection of metalloporphyrin heme oxygenase inhibitors based on potency and photoreactivity Pediatr Res 1993 33 195–200

    Article  CAS  Google Scholar 

  24. Vreman HJ, Gillman MJ, Stevenson DK In vitro inhibition of adult rat intestinal heme oxygenase by metalloporphyrins Pediatr Res 1989;26 362–5

    Article  CAS  Google Scholar 

  25. Vreman HJ, Wong RJ, Williams SA, Stevenson DK In vitro heme oxygenase isozyme activity inhibition by metalloporphyrins Pediatr Res 1998 43 202A

    Article  Google Scholar 

  26. Drummond GS, Rosenberg DW, Kappas A Intestinal heme oxygenase inhibition and increased biliary iron excretion by metalloporphyrins Gastroenterology 1992 102 1170–5

    Article  CAS  Google Scholar 

  27. Vallier HA, Rodgers PA, Stevenson DK Oral administration of zinc deuteroporphyrin IX 2,4 bis glycol inhibits heme oxygenase in neonatal rats Dev Pharmacol Ther 1991 17 220–2

    Article  CAS  Google Scholar 

  28. Drummond GS, Kappas A Sn-protoporphyrin inhibition of fetal and neonatal brain heme oxygenase. Transplacental passage of the metalloporphyrin and prenatal suppression of hyperbilirubinemia in the newborn animal J Clin Invest 1986 77 971–6

    Article  CAS  Google Scholar 

  29. Rodgers PA, Seidman DS, Wei PL, Dennery PA, Stevenson DK Duration of action and tissue distribution of zinc protoporphyrin in neonatal rats Pediatr Res 1996 39 1041–9

    Article  CAS  Google Scholar 

  30. Qato MK, Maines MD Prevention of neonatal hyperbilirubinaemia in non-human primates by Zn-protoporphyrin Biochem J 1985 226 51–7

    Article  CAS  Google Scholar 

  31. Kappas A, Drummond GS, Manola T, Petmezaki S, Valaes T Sn-protoporphyrin use in the management of hyperbilirubinemia in term newborns with direct Coombs-positive ABO incompatibility Pediatrics 1988 81 485–97

    CAS  Google Scholar 

  32. Wong RJ, Vreman HJ, Kadotani T, Stevenson DK Concentration of carbon monoxide (CO) in tissue J Invest Med 2000 48 123

    Google Scholar 

  33. Vreman HJ, Zentner AR, Wong RJ, Stevenson DK Carbon monoxide production and upregulation of heme oxygenase activity in mice after heme administration Pediatr Res 1999 45 231A

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, CA, USA

    Hendrik J Vreman PhD, Ronald J Wong BA & David K Stevenson MD

Authors
  1. Hendrik J Vreman PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ronald J Wong BA
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. David K Stevenson MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This work was supported by the National Institutes of Health, grants HD14426 and HL58013, the H. M. Lui Research Fund, the Hess Research Fund, and the Mary L. Johnson Research Fund.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Vreman, H., Wong, R. & Stevenson, D. Alternative Metalloporphyrins for the Treatment of Neonatal Jaundice. J Perinatol 21 (Suppl 1), S108–S113 (2001). https://doi.org/10.1038/sj.jp.7210645

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.jp.7210645

This article is cited by

Search

Advanced search

Quick links