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Phototherapy: From Ancient Egypt to the New Millennium

Journal of Perinatology volume 21, pages S7–S12 (2001)Cite this article

Abstract

Phototherapy with ultraviolet light was widely and successfully used in the past for treatment of a variety of diseases. Phototherapy with visible light alone has no benefit except in the therapy and prophylaxis of unconjugated hyperbilirubinemia. For this purpose, radiation in the region of ∼480 to 500 nm is most effective and radiation above ∼550 nm is useless. The principle effect of the treatment is not photodegradation of bilirubin, but conversion of the pigment to structural isomers that are more polar and more readily excreted than the normal, more toxic “dark” form of the pigment. This, coupled with some photooxidation of bilirubin, diminishes the overall pool of bilirubin in the body and lowers plasma levels. In the future, phototherapy may be supplanted by pharmacologic treatment, but in the near future, the most likely advance will be the introduction of novel forms of light production and delivery.

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References

  1. Goldberg B Heliotherapy Arch Phys Ther 1930 11 263

    Google Scholar 

  2. Krusen FH Physical Medicine Philadelphia: WB Saunders 1942 pp. 10–21

    Google Scholar 

  3. Horio T Skin disorders that improve by exposure to sunlight Clin Dermatol 1998 16 59

    Article  CAS  Google Scholar 

  4. Needham J, Gwei-Djen L Science and Civilisation in China vol. 5 Part 5 Cambridge: Cambridge University Press 1983 pp. 12 181–184

    Google Scholar 

  5. Downes A, Blunt TP Researches on the effect of light upon bacteria and other organisms Proc R Soc London 1877 26 488

    Google Scholar 

  6. Finsen NR Remarks on the red-light treatment of small-pox Br Med J 1903 1 1297

    Article  CAS  Google Scholar 

  7. Beckett RH Modern Actinotherapy London: William Heinemann Medical Books 1955 p. 9

    Google Scholar 

  8. Anderson WT The magic ultraviolet Arch Phys Ther 1930 11 482

    Google Scholar 

  9. Pleasonton AJ The Influence of the Blue Ray of Sunlight and the Blue Colour of the Sky in Developing Animal and Vegetable Life, in Arresting Disease, and in Restoring Health in Acute and Chronic Disorders to Human and Domestic Animals Philadelphia: Claxton, Remsen & Haffelfinger 1876

    Google Scholar 

  10. Kellogg JH Light Therapeutics Battle Creek, MI: Modern Medicine Publishing 1927

    Google Scholar 

  11. Anonymous Spectro-chrome therapy JAMA 1924 83 321

    Article  Google Scholar 

  12. Schwarcz J Colorful nonsense: Dinshah Ghadiali and his spectro-chrome device 2000 Available at: http://www.quackwatch.com/01QuackeryRelatedTopics/spectro.html

  13. Cremer RJ, Perryman PW, Richards DH Influence of light on the hyperbilirubinaemia of infants Lancet 1958 1 1094

    Article  CAS  Google Scholar 

  14. Lucey J, Ferreiro M, Hewitt J Prevention of hyperbilirubinemia of prematurity by phototherapy Pediatrics 1968 41 1047

    CAS  PubMed  Google Scholar 

  15. Dobbs RH, Cremer RJ Phototherapy Arch Dis Child 1975 50 833

    Article  CAS  Google Scholar 

  16. Broughton PMG, Rossiter EJR, Warren CBM, et al Effect of blue light on hyperbilirubinaemia Arch Dis Child 1965 40 666

    Article  CAS  Google Scholar 

  17. Martinez JC, Garcia HO, Otheguy LE, et al Control of severe hyperbilirubinemia in full-term newborns with the inhibitor of bilirubin production Sn-mesoporphyrin Pediatrics 1999 103 1

    Article  CAS  Google Scholar 

  18. Kikuchi A, Park S-Y, Miyatake H, et al Crystal structure of rat biliverdin reductase Nat Struct Biol 2001 8 221

    Article  CAS  Google Scholar 

  19. Pereira PJB, Macedo-Ribeiro S, Párraga A, et al Structure of human biliverdin-IXβ reductase, an early foetal bilirubin-IXβ producing enzyme Nat Struct Biol 2001 8 215

    Article  CAS  Google Scholar 

  20. Seidman DS, Moise J, Ergaz Z, et al A new blue light-emitting phototherapy device: a prospective randomized controlled study J Pediatr 2000 136 771

    CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Division of Gastroenterology and the Liver Center, University of California — San Francisco, San Francisco, CA, USA

    Antony F McDonagh PhD

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  1. Antony F McDonagh PhD
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This work was supported in part by grants DK 26307 and GM 36633 from the National Institutes of Health.

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McDonagh, A. Phototherapy: From Ancient Egypt to the New Millennium. J Perinatol 21 (Suppl 1), S7–S12 (2001). https://doi.org/10.1038/sj.jp.7210625

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