The activity of transposable elements can be induced by environmental and population factors and in particular by stresses in various organisms. A consequence of the increase in transposable element mobility is the creation of new genetic variability that can be useful in the face of stressful conditions. In this review, results supporting this hypothesis are presented and discussed. The main question is how stress induces the activity of transposable elements. We discuss hypotheses based upon the existence of promoters or fixation sites of transcription activators in the untranslated regions of transposable elements, similar to those found in regulatory regions of host defence genes.
Interaction of genome and environment
In the natural world, individuals, populations and species all have to cope with environmental change. Individual organisms and their cells have to adapt physiologically through responses that are immediate and reversible. At the population and species levels, selection may lead to genetic changes and to the evolution of the inherited characteristics of an individual organism. In such organisms this long-term response is irreversible.
During the last two decades several authors have reported that stress increases the genetic variability of many quantitative traits in a population, see for instance Imasheva et al., (1998), including life history and morphology (Hoffmann & Parsons, 1997). This genetic variability may have various origins. For example, different genes may be expressed in normal as opposed to stressful environments. It has also been shown recently that genetic variability can be hidden by buffering proteins such as Hsp90 (Rutherford & Lindquist, 1998). This variability can be revealed by stress and then maintained when the protein function is restored. Finally, mutator mechanisms can be induced by stress. These are the origin of the genetic variability that allows selection to take place in response to environmental changes. At least two mechanisms are frequently described: those involving the SOS response (the activation of mutagenic activity) or the MRS response (inhibition of an antimutagenic system, the mismatch repair system) (Taddei et al., 1997) and those involving transposable elements (TEs) (Capy et al., 1997). Here we review and discuss findings of the impact of TEs on the host genome under stressful conditions and also summarize the various models put forward to account for these findings.
What is stress?
Before we discuss the relationship between TEs and their host genomes in a stressful environment, it is important to define stress. According to Koehn & Bayne (1989) stress reduces the fitness of an organism. Hoffmann & Parsons (1997) have proposed a definition which includes ‘any environmental change that drastically reduces the fitness of an organism’. There are also several more precise definitions of stress, discussed by Bijlsma & Loeschcke (1997), which range over various biological levels from molecules to populations according to the intensity of the environmental changes and the organism or population involved. In addition, these authors identify two classes of stress defined according to the response of the organism: those evoking a physiological response (the individual context), and those evoking a phenotypic and/or a genetic response (the evolutionary context). In this review we will consider this last class of stress. Moreover, the genetic consequences of the relationships between transposable elements and stresses will be considered at individual and population levels.
Transposable elements and genomes
In the late 1970s transposable elements were described as parasitic sequences because they use the host machinery for their own amplification (Doolittle & Sapienza, 1980; Orgel & Crick, 1980). Since the beginning of the 1980s detailed analysis has been carried out on their polymorphism (DNA and protein), copy numbers, chromosomal location, activation, regulation and transposition rates in natural and laboratory populations and between closely related species. In some cases they have been domesticated by the host genomes (Miller et al., 1997; Nouaud et al., 1999). Several other findings supporting this view have also been published (see the special issues of Genetica. on transposable elements in 1992, 1994, 1997 and 2000).
TEs are a major component of all genomes and represent between 3 to 50% of the content of the genome, depending on the species (Capy et al., 1997). While TE interactions with the host genome remain poorly understood there are several examples of their impact on host functioning, structure and evolution. For example, Tn, bacterial composite elements (elements flanked by Insertion Sequences), provide several examples in which a gene involved in antibiotic resistance can be horizontally transferred, see for instance Berg & Howe (1989) and more recently, Hall (1997) and Recchia & Hall (1997). In Drosophila melanogaster, LINE-like elements such as TART and Het-A are used as a ‘cap’ at the extremities of the chromosomes to prevent their degradation (Pardue et al., 1997). Also in this species, the hobo element is involved in chromosomal inversions (Lim, 1988; Lyttle & Haymer, 1992; Lim & Simmons, 1994; Ladeveze et al., 1998). Gene regulation under the partial or complete control of retrotransposon LTRs (long-terminal repeats) or solo LTRs left by retrotransposons are another illustration of TE effects on host genome evolution (White et al., 1994; Britten, 1996; McDonald et al., 1997). This is also seen in the human α-amylase gene (Ting et al., 1992). Similarly, in the Saccharomyces cerevisiae genome, 331 Ty insertions (85% of which are solo LTRs) have been detected (Kim et al., 1998). These sequences are frequently inserted in tRNA genes or other transcribed genes (Hani & Feldmann, 1998). Therefore, they may have an impact on the expression profile of these genes. Thus, many of the interactions between TEs and their host genomes can be seen as a domestication of the former by the latter, or as a coevolution between the two entities.
Stresses and transposable elements
McClintock (1984) suggested that transposable element activity could be a response to challenges to the genome. Two approaches can be used to test this hypothesis. The first is the application of stresses to genetically controlled organisms. This is a direct investigation in which genetic modifications of the organism can be followed in terms of variability, structure and function. The second approach is the analysis of natural populations of the same species living in different conditions. This indirect investigation may also reveal the effect of environmental factors.
In adaptive mutagenesis in bacteria, discussed by Hall (1998), the IS elements may play an important role since these elements can transpose in ‘response to external environmental signals that are related to the fitness function at the host level’ (Hall, 2000). In such experiments, stresses correspond to deficient substrates. In E. coli, silent operons can be activated by IS insertions and then contribute to the fitness of the cell (Hall, 2000). For instance, β-glucoside operons are silent in wildtype strains and could be activated by IS elements to use β-glucoside sugar as sources of carbon and energy.
Wessler (1996) and Grandbastien (1998) have reviewed a number of elements in plants (mainly retrotransposons) that are turned on by stresses. For example, it was clearly shown that transcription of the Tnt1 element of Nicotiana tabacum can be induced following several biotic and abiotic stresses (Grandbastien et al., 1997).
In Drosophila simulans, the copy number of the 412 element increases with latitude following the minimum temperature (Viera & Biémont, 1996). This phenomenon has been observed on various continents and on both sides of the equator. Independently, in the same species, Giraud & Capy (1996) have described a latitudinal cline between tropical Africa and Europe for the somatic activity of the mariner element, again suggesting an effect of factor(s) closely related to temperature. This is in agreement with laboratory results showing an effect of the developmental temperature on both somatic (Chakrani et al., 1993) and germline (Garza et al., 1991) excision rates.
The temperature effect is one of the most extensively tested stresses. While this factor is suspected of affecting several transposable elements, we must be cautious in generalising results obtained from one element in one population. In Drosophila, some findings seem to suggest the mobilisation of retrotransposon elements after heat shock (Ratner et al., 1992; Vasilyeva et al., 1999), while others show no effect of similar stresses (Arnault & Dufournel, 1994; Arnault et al., 1997). In addition, several transposable elements can be mobilized by the passage to cell culture (Di Franco et al., 1992), which may serve as a source of stress.
What these observations tell us
The effect of stress on the behaviour of transposable elements prompts several comments. Firstly, the induction of TE activity has been demonstrated for only a few elements. Different populations and strains do not respond in the same way, as illustrated by the response of copia element transcription to temperature in D. melanogaster (Arnault & Dufournel, 1994). This may reflect not only the sensitivity of population/strain genomes to a given stress, but also the effect of the host genome on TE activity.
Secondly, TEs on which stresses may have some effect are generally of class I (elements moving by an RNA intermediate and using a reverse transcriptase). Are the class II elements (moving by a DNA intermediate) therefore insensitive to environmental stresses? Several results suggest not. For example, analysis of mariner elements in natural populations of D. simulans reveals the existence of a latitudinal cline in somatic activity (Giraud & Capy, 1996). This is also seen in the P and hobo elements in D. melanogaster, for which the hybrid dysgenesis syndrome is observed at 29°C and 25°C respectively (Kidwell, 1977; Blackman et al., 1987). In Antirrhinum majus, the excision rates of copies of the Tam3 element inserted in the palrec-2 and nivrec-98 alleles are higher at 15°C than at 25°C (Coen et al., 1989). Similar effects have also been reported for the Tn3 element of E. coli (Kretschmer & Cohen, 1979). Finally, as previously mentioned, IS elements of bacteria are involved in the response to stress (Hall, 1998).
Thirdly, analyses of TE dynamics after stress remain difficult to interpret (Jouan-Dufournel et al., 1996). Marked elements with a reporter gene for detecting the transcriptional induction of the element (for Class I and II elements), or reporter genes with a TE insertion to detect excision events (for Class II elements) can also be used. In these cases somatic events can easily be detected, see for instance Capy et al., (1990) and Grandbastien, (1998). Whether this somatic induction has effects on the next generation, both on somatic and germ lines, remains uncertain. To find out, the dynamics of TEs within a species will have to be considered. For several elements, at least in Drosophila, it is assumed that a product of TE activity in females can be transferred to the next generation through the cytoplasm of the eggs. This has been suggested for several Class II elements following the description of maternal effects for the hobo (Ho et al., 1993), P (Kidwell, 1981), I (Bucheton, 1979) and mariner (Bryan & Hartl, 1988) elements. For the last of these, analyses of two successive generations have shown higher activity in the offspring of females carrying active elements (Bryan & Hartl, 1988). In A. majus, Tam1 and Tam2 elements also show non-Mendelian inheritance, suggesting cytoplasmic transmission (Coen et al., 1989). Therefore, a relationship may exist between the somatic activity of an element in a given generation and its germline activity in the following generations.
It is also important to consider how the stresses are applied. In plants, specifically for the Tnt1 element, the stresses were applied locally (one part of the plant like a sector of a leaf) and led to local responses. Moreover, in most cases the stresses led to cell death in the affected tissues. In Drosophila, stresses were generally applied to the entire organism and led to a general response. In such cases the existence of a general system called VAMOS, similar to the SOS response of bacteria, has been suggested (Brégliano et al., 1995; Laurençon & Brégliano, 1995; Laurençon et al., 1997). It has been shown that a repair-recombination system might exist in D. melanogaster, and that its efficiency could be modulated by endogenous and environmental factors. Moreover, the reactivity level of R strains of the I-R system seems to be related to the DNA repair system. Therefore, a general perturbation may lead to modifications of transposable element regulation.
Stressful conditions can be applied for short or long periods, for the whole life of an organism or even over several generations. This last situation is encountered when populations face long-lasting environmental change. So, the creation of new genetic variability induced by the activity of transposable elements may favour a more rapid adaptation.
Finally, there is the question of how stress can induce the activity of an element. It is possible that in most cases these effects are not direct. Indeed, when faced by stress, an organism may have to induce one or several responses at the physiological and/or genetic level. In the latter case, defence genes may be activated by transcriptional activators. The correlated response of the transposable elements could be due to the presence of fixation sites of transcription activators in their regulatory regions. This phenomenon is suspected for the Tnt1 element in which the U3 region exhibits short sequences similar to those found in the regulatory motifs of the defence genes (Grandbastien et al., 1997). In Drosophila, detailed analyses of the copia and mariner regulatory sequences show the existence of motifs very similar to those of hsp promoters (Strand & McDonald, 1985; Chakrani et al., 1993; McDonald et al., 1997). This suggests that after stress, a proteolytic cascade leading to the release of transcription activators require for the induction of the host defence genes, could also induce the activity of some TEs (Fig. 1). Such phenomena at the individual level may also have some implications for the population level. Indeed, this leads to an increase in the genetic variability upon which selection can draw, so helping the population to confront stress (Fig. 1).
These observations raise the question of the origin of these fixation sites or promoters in transposable elements. Extensive comparisons of TE sequences during the past decade suggest that they are like construction sets or assemblages of different modules, each with a different history. This is supported by analysis of the variability of the structure of retrotransposons. For example, the similarities observed between the reverse transcriptase of retrotransposons and retroviruses, and also with those of retrons and group II introns, suggest that this domain comes from the same ancestral sequence (McClure, 1993; Xiong & Eickbush, 1990). Again, the similarities of the class I element integrases with transposases of class II elements also suggest evolutionary relationships (Capy et al., 1996). More recently, the description of elements in fungi, such as Ant1 in Aspergillus niger (Glayser et al., 1995) and hupfer in Beauvaria bassiana (Maurer et al., 1997) in which foreign sequences were found, reinforce the idea that the acquisition of new functions is possible.
In this respect, the presence of fixation sites of host transcription factors or promoters could be an acquisition of TEs or an acquisition by the host defence genes of TE regions. This is suggested by the recently reported relationship between transposable elements and the immune repertoire of vertebrates (Agrawal et al., 1998). More specifically, the RAG1 and RAG2 (recombination-activating genes) can form a protein able to induce transposition. This similarity, initially mentioned by Dreyfus (1992), is strongly indicative of an ancient transposable element which has been tamed by the host genome (Plasterk, 1998).
While the plasticity of the genome and TEs is now generally accepted, the interactions between these two entities are still not clearly understood. Stresses seem to induce the activity of some TEs but the underlying mechanisms remain hypothetical. One explanation can be sought in the similarity of the activation processes of host defence genes and transposable elements. In this hypothesis the question that remains to be solved is the origin of such similarities. Is it the result of a domestication of TEs by the host genome or of TEs acquiring host sequences? These two interpretations are not, of course, mutually exclusive.
Another explanation could be that stresses have induced a destabilization of the genome, leading to the malfunction of several genetic systems. In this case TE induction could be a secondary rather than a direct effect of the stress. For example, the SOS and MRS systems in bacteria and the putative VAMOS system in Drosophila could play a central role in the host response, and their induction may have several effects on the functioning of others systems, including TE regulation.
Agrawal, A., Eastman, Q. M. and Schatz, D. G. (1998). Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system. Nature, 394: 744–751.
Arnault, C. and Dufournel, I. (1994). Genome and stresses: reactions against aggressions, behavior of transposable elements. Genetica, 93: 149–160.
Arnault, C., Lœvenbruck, C. and Biémont, C. (1997). Transposable element mobilization is not induced by heat shocks in Drosophila melanogaster. Naturwissenschaften, 84: 410–414.
Berg, D. E. and Howe, M. M. (1989). Mobile DNA American Society for Microbiology, Washington, DC.
Bijlsma, R. and Loeschcke, V. (1997). Environmentam Stress Adaptation and Evolution, Birkhäuser. Berlin.
Blackman, R. K., Grimaila, R., Koehler, M. M. D. and Gelbart, W. M. (1987). Mobilization of hobo elements residing within the decapentaplegic gene complex: suggestion of a new hybrid dysgenesis system in Drosophila melanogaster. Cell, 49: 497–505.
Brégliano, J. C., Laurençon, A. and Degroote, F. (1995). Evidence for an inducible repair-recombination system in the female germ line of Drosophila melanogaster I. Induction by inhibitors of nucleotide synthesis and by gamma rays. Genetics, 141: 571–578.
Britten, R. J. (1996). Cases of ancient mobile element DNA insertions that now affect gene regulation. Mol Phylogenet Evol, 5: 13–17.
Bryan, G. J. and Hartl, D. L. (1988). Maternally inherited transposons excision in Drosophila simulans. Science, 240: 215–217.
Bucheton, A. (1979). Non-Mendelian female sterility in Drosophila melanogaster: influence of aging and thermic treatments. III. Cumulative effects induced by these factors. Genetics, 93: 131–142.
Capy, P., Bazin, C., Higuet, D. and Langin, T. (1997). Dynamic and Evolution of Transposable Elements, R.G. Landes Company, Austin, Texas, USA.
Capy, P., Chakrani, F., Lemeunier, F., Hartl, D. L. and David, J. R. (1990). Active mariner elements are widespread in natural populations of Drosophila simulans. Proc R Soc Lond (Biol), 242: 57–960.
Capy, P., Vitalis, R., Langin, T., Higuet, D. and Bazin, C. (1996). Relationships between transposable elements based upon the integrase-transposase domains: is there a common ancestor? J Mol Evol, 42: 359–369.
Chakrani, F., Capy, P., David, J. R. (1993). Developmental temperature and somatic excision rate of mariner transposable element in three natural populations of Drosophila simulans. Genet Sel Evol, 25: 121–132.
Coen, E. S., Robbins, T. P. and Almeida, J. (1989). Consequences and mechanisms of transposition in Antirrhinum majus. Mobile DNA (Ed. by D. E. Berg). & M. M. Howe, pp. 413–436. American Society for Microbiology, Washington DC.
Di Franco, C., Pisano, C., Fourcade-Peronnet, F., Echalier, G. and Junakovic, N. (1992). Evidence for de novo rearrangements of Drosophila transposable elements induced by the passage to the cell culture. Genetica, 87: 65–73.
Doolittle, W. F. and Sapienza, C. (1980). Selfish genes, the phenotype paradigm and genome evolution. Nature, 284: 601–603.
Dreyfus, D. H. (1992). Evidence suggesting an evolutionary relationship between transposable elements and immune system recombination sequences. Mol Immunol, 29: 807–810.
Garza, D., Medhora, M., Koga, A. and Hartl, D. L. (1991). Introduction of the transposable element mariner into the germline of Drosophila melanogaster. Genetics, 128: 303–310.
Giraud, T. and Capy, P. (1996). Somatic activity of the mariner transposable element in natural populations of Drosophila simulans. Proc Roy Soc Lond (Biol), 263: 1481–1486.
Glayser, D. C., Roberts, I. N., Archer, D. B. and Oliver, R. P. (1995). The isolation of Ant1 a transposable element from Aspergillus niger. Mol Gen Genet, 249: 432–438.
Grandbastien, M. A. (1998). Activation of plant retrotransposons under stress conditions. Trends Plants Science, 3: 181–187.
Grandbastien, M. -A., Lucas, H., Morel, J.-B., Mhiri, C., Vernhettes, S. and Casacuberta, J. M. (1997). The expression of the tobacco Tnt1 retrotransposon is linked to the plant defense responses. Genetica, 100: 241–252.
Hall, R. M. (1997). Mobile gene cassettes and integrons: moving antibiotic resistance genes in gram-negative bacteria. Ciba Foundation Symposium, 207: 192–202.
Hall, B. G. (1998). Adaptive mutagenesis: a process that generates almost exclusively beneficial mutations. Genetica, 102–103, 109–125.
Hall, B. G. (2000). Mobile elements as activators of cryptic genes in. E Coli Genetica, in press.
Hani, J. and Feldmann, H. (1998). tRNA genes and retroelements in the yeast genome. Nucl Acids Res, 26: 689–696.
Ho, Y. T., Weber, S. M. and Lim, J. K. (1993). Interacting hobo transposons in an inbred strain and interaction regulation in hybrids of. D melanogaster Genetics, 134: 895–908.
Hoffmann, A. A. and Parsons, P. A. (1997). Extreme Environmental Change and Evolution, Cambridge University Press.
Imasheva, A. G., Loeschcke, V., Zhivotovsky, L. A. and Lazebny, O. E. (1998). Stress temperatures and quantitative variation in Drosophila melanogaster. Heredity, 81: 246–253.
Jouan-Dufournel, I., Cosset, F. L., Contamine, D., Verdier, G. and Biémont, C. (1996). Transposable elements behavior following viral genomic stress in Drosophila melanogaster inbred line. Journal of Mol Evol, 43: 19–27.
Junakovic, N., Di Franco, C., Barsanti, P. and Palumbo, G. (1986). Transposition of copia-like nomadic elements can be induced by heat shock. J Mol Evol, 24: 89–93.
Kidwell, M. G. (1977). Reciprocal differences in female recombination associated with hybrid dysgenesis in Drosophila melanogaster. Genet Res, 30: 77–88.
Kidwell, M. G. (1981). Hybrid dysgenesis in Drosophila melanogaster: the genetics of cytotype determination in a neutral strain. Genetics, 98: 275–290.
Kim, J. M., Vanguri, S., Boeke, J. D., Gabriel, A. and Voytas, D. F. (1998). Transposable elements and genome organization: a comprehensive survey of retrotransposons revealed by the complete Saccharomyces cerevisiae genome sequence. Genome Res, 8: 464–478.
Koehn, R. K. and Bayne, B. L. (1989). Towards a physiological and genetical understanding of the energitics of the stress response. Biol J Linn Soc, 37: 157–171.
Kretschmer, P. J. and Cohen, S. N. (1979). Effect of temperature on translocation frequency of the Tn3 element. J Bacteriol, 139: 515–519.
Ladeveze, V., Aulard, S., Chaminade, N., Periquet, G. and Lemeunier, F. (1998). Hobo transposons causing chromosomal breakpoints. Proc R Soc Lond B Biol Sci, 265: 1157–1159.
Laurençon, A. and Brégliano, J. C. (1995). Evidence for an inducible repair-recombination system in the female germ line of Drosophila melanogaster. II. Differential sensitivity to gamma rays. Genetics, 141: 579–585.
Laurençon, A., Gay, F., Ducau, J. and Bregliano, J. C. (1997). Evidence for an inducible repair-recombination system in the female germ line of Drosophila melanogaster. III. Correlation between reactivity levels, crossover frequency and repair efficiency. Genetics, 146: 1333–1344.
Lim, J. (1988). Intrachromosomal rearrangements mediated by hobo transposons in Drosophila melanogaster. Proc Natl Acad Sci USA, 85: 9153–9157.
Lim, J. and Simmons, M. J. (1994). Gross chromosome rearrangements mediated by transposable elements in Drosophila melanogaster. Bioessays, 16: 269–275.
Lyttle, T. W. and Haymer, D. S. (1992). The role of transposable element hobo in the origin of the endemic inversions in wild populations of Drosophila melanogaster. Genetica, 83: 113–126.
Maurer, P., Réjasse, A., Capy, P., Langin, T. and Riba, G. (1997). Isolation of the transposable element Hupfer from the entomopathogenic fungus Beauveria bassiana by insertion mutagenesis in the nitrate reductase structural gene. Mol Gen Genet, 256: 195–202.
McClintock, B. (1984). The significance of responses of the genome to challenge. Science, 226: 792–801.
McClure, M. (1993). Evolutionary history of reverse transcriptase. In: Skalka, M. and Goff, S. P. (eds) Reverse Transcriptase, pp. 425–444. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
McDonald, J. F., Matyunina, L. V., Wilson, S., Jordan, I. K., Bowen, N. J. and Miller, W. J. (1997). LTR retrotransposons and the evolution of eukaryotic enhancers. Genetica, 100: 3–13.
Miller, W. J., Kruckenhauser, L. and Pinsker, W. (1997). The impact of TEs on genome evolution in animals and plants. In: Wöhrmann, K., Tomiuk, J. and Sentker, A. (eds) Transgenic Organisms: Risk Assessement of Deliberate Release, pp. 21–35. Birkhäuser Verlag, Basel.
Nouaud, D., Boeda, B., Levy, L. and Anxolabehere, D. (1999). A P element has induced intron formation in Drosophila. Mol Biol Evol, 16: 1503–1510.
Orgel, L. E. and Crick, F. H. C. (1980). Selfish DNA: the ultimate parasite. Nature, 284: 604–607.
Pardue, M.-L., Danilevskaya, O. N., Traverse, K. L. and Lowenhaupt, K. (1997). Evolutionary links between telomeres and transposable elements. Genetica, 100: 73–84.
Plasterk, R. (1998). Ragtime jumping. Nature, 394: 718–719.
Ratner, V. A., Zabanov, S. A., Kolesnikova, O. V. and Vasilyeva, L. A. (1992). Induction of the mobile genetic element Dm-412 transpositions in the Drosophila genome by heat shock treatment. Proc Natl Acad Sci USA, 89: 5650–5654.
Recchia, G. D. and Hall, R. M. (1997). Origins of the mobile gene cassettes found in integrons. Trends Microbiol, 5: 389–394.
Rutherford, S. L. and Lindquist, S. (1998). Hsp90 as a capacitor for morphological evolution. Nature, 396: 336–342.
Strand, D. J. and McDonald, J. F. (1985). Copia is transcriptionally responsive to environmental stress. Nucl Acids Res, 13: 4401–4410.
Taddei, F., Vulic, M., Radman, M. and Matic, I. (1997). Genetic variability and adaptation to stress. Exs, 83: 271–290.
Ting, C. N., Rosenberg, M. P., Snow, C. M., Samuelson, L. C. and Meisler, M. H. (1992). Endogenous retroviral sequences are required for tissue-specific expression of a human salivary amylase gene. Genes Dev, 6: 1457–1465.
Vasilyeva, L. A., Bubenshchikova, E. V. and Ratner, V. A. (1999). Heavy heat shock induced retrotransposon transposition in Drosophila. Genet. Res. 111–119.
Viera, C. and Biémont, C. (1996). Geographical variation in insertion site number of retrotransposon 412 in Drosophila simulans. J Mol Evol, 42: 443–451.
Wessler, S. R. (1996). Plant retrotransposons: turned on by stress. Current Biol, 6: 959–961.
White, S. E., Habera, L. F. and Wessler, S. R. (1994). Retrotransposons in the flanking regions of normal plant genes: a role for copia-like elements in the evolution of the gene structure and expression. Proc Natl Acad Sci USA, 91: 11792–11796.
Xiong, Y. and Eickbush, T. H. (1990). Origin and evolution of retroelements based upon their reverse transcriptase sequences. EMBO J, 9: 3353–3362.
Zou, S., Kim, J. M. and Voytas, D. F. (1996). The Saccharomyces retrotransposon Ty5 influences the organization of chromosome ends. Nucl Acids Res, 24: 4825–4831.
Rights and permissions
About this article
Cite this article
Capy, P., Gasperi, G., Biémont, C. et al. Stress and transposable elements: co-evolution or useful parasites?. Heredity 85, 101–106 (2000). https://doi.org/10.1046/j.1365-2540.2000.00751.x
- transposable elements
This article is cited by
Jasmonates and Histone deacetylase 6 activate Arabidopsis genome-wide histone acetylation and methylation during the early acute stress response
BMC Biology (2022)
Stress does not induce a general transcription of transposable elements in Drosophila
Molecular Biology Reports (2022)
Transcriptional activity of transposable elements along an elevational gradient in Arabidopsis arenosa
Mobile DNA (2021)
Comparative genomic and transcriptomic analyses of transposable elements in polychaetous annelids highlight LTR retrotransposon diversity and evolution
Mobile DNA (2021)
Retrotransposons as pathogenicity factors of the plant pathogenic fungus Botrytis cinerea
Genome Biology (2021)