Sir,
I read the article by Jonas et al1 on ‘Branch retinal vein occlusion treated by intravitreal triamcinolone acetonide’. I disagree with their conclusion that an intravitreal injection of triamcinolone can increase visual acuity in patients with branch retinal occlusion. If one looks in Tables 2 and 3 at the preoperative and study end visual acuities of the study and control groups there is no significant change in acuity over the study period for either group. In addition, there is no significant difference between the groups at either time point. Given that a total of 19 comparisons of mean visual acuity were performed I suggest that a correction of the level of significance should have been performed.2 This would have meant that none of the comparisons of acuity at intermediate time points in Tables 2 and 3 would have reached statistical significance.
References
Jonas JB, Akkoyun I, Kamppeter B, Kreissig I, Degenring RF . Branch retinal vein occlusion treated by intravitreal triamcinolone acetonide. Eye 2005; 19: 65–71.
Altman DG . Practical Statistics for Medical Research, 1st edn. Chapman & Hall: London, 1991.
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Wilkins, M. Reply to intrevitreal triamcinolone for branch retinal vein occlusion. Eye 20, 727–728 (2006). https://doi.org/10.1038/sj.eye.6701947
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DOI: https://doi.org/10.1038/sj.eye.6701947