Clinical Study | Published:

Clinical, radiological and pathological examination of periocular dermoid cysts: evidence of inflammation from an early age

Eye volume 16, pages 507512 (2002) | Download Citation

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Abstract

Introduction Periocular dermoid cysts are common and leakage of the lipid or keratin contents leads to an inflammation—often asymptomatic—around the cyst, which may cause adherence of the dermoid cyst to neighbouring structures.

Purpose To investigate the frequency of clinical and radiological signs of inflammation with periocular dermoid cysts, to relate this to the histopathological examination of the excised specimens, and to assess whether the degree of inflammation is related to age at presentation.

Patients and Methods A retrospective non-comparative series of 124 patients with periocular dermoid cysts that had undergone imaging. Case-notes were reviewed for clinical and histopathological details and there was independent review of the radiological imaging.

Results Surgery was undertaken at between 1 and 66 years of age, most patients being under 10 years, and the duration of symptoms varied from 4 weeks to 30 years. Symptoms of inflammation—mainly intermittent lid swelling with localised redness and pain—occurred in all age groups, the proportion being greatest in the fourth decade. Clinical signs of inflammation at the time of clinic visit were relatively few, although 8% had some localised erythema and 7% had tenderness at the site of lesion.

In more than two-thirds of the excised cysts, pathological examination demonstrated various degrees of chronic inflammation, even in those cysts removed before the age of 5 years.

Conclusion Even if the patient does not have symptoms or signs of inflammation, most periocular dermoid cysts show histological evidence of inflammation due to leakage of the lipid and keratin contents from the cyst, the incidence being similar at all ages.

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References

  1. 1.

    , , . Dermoid cysts in children. Pediatrics 1976; 57: 379–382

  2. 2.

    , , , , . Space-occupying orbital masses in children. A review of 250 consecutive biopsies. Ophthalmology 1986; 93: 352–364

  3. 3.

    , , . Orbital dermoids: clinical presentation and management. Brit J Ophthalmol 1984; 68: 642–652

  4. 4.

    . Frequency and differential diagnosis of orbital disease In: Rootman J (ed) Diseases of the Orbit. A Multidisciplinary Approach JB Lippincott Company: Philadelphia 1988 p 124

  5. 5.

    , , . Orbital dermoid cyst. Eye 1987; 1: 504–511

  6. 6.

    , , , . Dermoid cyst: 16 year survey. Ophthalmic Plast Reconstr Surg 1995; 11: 187–192

  7. 7.

    , , , . The frequency and clinical significance of bone involvement in outer canthus dermoid cysts. Brit J Ophthalmol 1993; 77: 789–794

  8. 8.

    , , , . Orbital dermoid cyst: clinicopathological correlation, classification and management. The 1997 Josephine Schueler Lecture. Ophthalmic Plast Reconstr Surg 1997; 13: 265–276

  9. 9.

    , , , . Orbital Tumors, 3rd edn Raven Press: New York 1994 pp 53–61

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Author information

Affiliations

  1. Moorfields Eye Hospital London EC1V 2PD, UK

    • Y Abou-Rayyah
    • , G E Rose
    • , H Konrad
    • , S J Chawla
    •  & I F Moseley

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Corresponding author

Correspondence to G E Rose.

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DOI

https://doi.org/10.1038/sj.eye.6700045