Abstract
A series of benzo(b)thiophenesulfonamide 1,1-dioxide derivatives (BTS) have been designed and synthesized as candidate antineoplastic drugs. Several of these compounds have shown in vitro cytotoxic activity on leukaemic CCRF-CEM cells. The cytotoxic BTS, but not the inactive ones, were able to inhibit a tumour cell-specific NADH oxidase activity present in the membrane of CCRF-CEM cells. © 2001 Cancer Research Campaign http://www.bjcancer.com
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Alonso, M., Encío, I., Martínez-Merino, V. et al. New cytotoxic benzo(b)thiophenilsulfonamide 1,1-dioxide derivatives inhibit a NADH oxidase located in plasma membranes of tumour cells. Br J Cancer 85, 1400–1402 (2001). https://doi.org/10.1054/bjoc.2001.2083
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DOI: https://doi.org/10.1054/bjoc.2001.2083
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