Abstract
The relation between relative body weight and colorectal cancer among women is unclear. In a large prospective cohort study, we found a positive association only for distal cancers among younger women that became attenuated at older ages. These results support previous reports in which results were stratified by age or colorectal cancer site. © 2001 Cancer Research Campaign
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References
Crandall C (1999) Estrogen replacement therapy and colon cancer: a clinical review. J Womens Health Gend Based Med 8: 1155–1166
Dietz A, Newcomb P, Marcus P and Storer B (1995) The association of body size and large bowel cancer risk in Wisconsin (United States) women. Cancer Causes Control 6: 30–36
Gerhardsson de Verdier M, Hagman U, Steineck G, Rieger A and Norell S (1990) Diet, body mass and colorectal cancer: a case-referent study in Stockholm. Int J Cancer 46: 332–338
Giovannucci E (1995) Insulin and colon cancer. Cancer Causes Control 6: 164–179
Giovannucci E, Ascherio A, Rimm E, Colditz G, Stampfer M and Willett W (1995) Physical activity, obesity, and risk for colon cancer and adenoma in men. Ann Intern Med 122: 327–334
Giovannucci E, Colditz GA, Stampfer MJ and Willett WC (1996) Physical activity, obesity, and risk of colorectal adenoma in women (United States). Cancer Causes Control 7: 253–263
Giovannucci E, Pollak MN, Platz EA, Willett WC, Stampfer MJ, Majeed N, Colditz GA, Speizer FE and Hankinson SE (2000) A prospective study of plasma insulin-like growth factor-I and binding protein-3 and risk of colorectal neoplasia in women. Cancer Epidemiol Biolmarkers Prev 9: 345–349
Graham S, Marshall J, Haughey Mittelman A, Swanson M, Zielezny M, Byers T, Wilkinson G and West D (1988) Dietary epidemiology of cancer of the colon in Western New York. Am J Epidemiol 128: 490–503
Grodstein F, Martinez ME, Platz EA, Giovannucci E, Colditz GA, Kautzky M, Fuchs C and Stampfer MJ (1998) Postmenopausal hormone use and risk for colorectal cancer adenoma. Ann Intern Med 128: 705–712
Kune G, Kune S and Watson LF (1990) Body weight and physical activity as predictors of colorectal cancer risk. Nutr Cancer 13: 9–17
Kuskowska-Wolk A, Karlsson P and Stolt M Rössner S (1989) The predictive validity of body mass index based on self-reported weight and height. Int J Obesity 13: 441–453
Le Marchand L, Wilkens L and Mi MP (1992) Obesity in youth and middle age and risk of colorectal cancer in men. Cancer Causes Control 3: 349–354
Le Marchand L, Wilens L, Kolonel N, Hankin J and Lyu LC (1997) Associations of sedentary lifestyle, obesity, smoking, alcohol use, and diabetes with the risk of colorectal cancer. Cancer Research 57: 4787–4794
Lew E and Garfinkel L (1979) Variations in mortality by weight among 750,000 men and women. J Chron Dis 32: 563–576
Ma J, Pollak MN, Giovannucci E, Chan JM, Tao Y, Hennekens CH and Stampfer MJ (1999) Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3. J Natl Cancer Inst 91: 620–625
Martinez M, Giovannucci E, Spiegelman D, Hunter D, Willett W and Colditz G (1997) Leisure-time physical activity, body size, and colon cancer in women. J Natl Cancer Inst 89: 948–955
Philips R and Snowdon D (1985) Dietary relationships with fatal colorectal cancer among Seventh-Day Adventists. J Natl Cancer Inst 74: 307–317
Powell DR, Suwanichkul A, Cubbage ML, DePaolis LA, Snuggs MB and Lee PD (1991) Insulin inhibits transcription of the human gene for insulin-like growth factor-binding protein-1. J Biol Chem 266: 18868–18876
Potter J (1996) Nutrition and colorectal cancer. Cancer Causes Control 7: 127–146
Potter JD, Bostick RM, Grandits GA, Fosdick L, Elmer P, Wood J, Grambsch P and Louis TA (1996) Hormone replacement therapy is associated with lower risk of adenomatous polyps of the large bowel: the Minnesota Cancer Prevention Research Unity Case-Control Study. Cancer Epidemiol Biomarkers Prev 5: 779–784
Russo A, Franceschi S, La Vecchia C, Dal Maso L, Montella M, Conti E, Giacosa A, Falcini F and Negri E (1998) Body size and colorectal-cancer risk. Int J Cancer 78: 161–165
Shike M (1996) Body weight and colon cancer. Am J Clin Nutr 63: 442S–444S
Slattery ML, Potter J, Caan B, Edwards S, Coates A, Ma KN and Berry TD (1997) Energy balance and colon cancer: beyond physical activity. Cancer Research 57: 75–80
Terry P, Giovannuci E, Michels KB, Bergkvist L, Hansen H, Holberg L and Wolk A (2001) Fruit, vegetables, dietary fiber, and risk of colorectal cancer. J Natl Cancer Inst 91: 525–533
Troisi R, Schairer C, Chow W, Schatzkin A, Brinton A and Fraumini J (1997) A prospective study of menopausal hormones and risk of colorectal cancer. Cancer Causes Control 8: 130–138
West DW, Slattery ML, Robison LM, Schuman KL, Ford MH, Mahoney AW, Lyon JL and Sorensen AW (1989) Dietary intake and colon cancer: sex-and site-specific associations. Am J Epidemiol 130: 883–894
White E, Jacobs EJ and Daling JR (1996) Physical activity in relation to colon cancer in middle-aged men and women. Am J Epidemiol 144: 42–50
WHO (1998). Obesity: preventing and managing the global epidemic, World Health Organization: Geneva (June 3–5, 1997).
Willett W and Stampfer M (1986) Total energy intake: implications for epidemiologic analyses. Am J Epidemiol 124: 17–27
Willett WC, Howe GR and Kushi LH (1997) Adjustment for total energy intake in epidemiologic studies. Am J Clin Nutr 65: 1220S–1228S
World Cancer Research Fund (1997). Food, nutrition and the prevention of cancer: a global perspective, Washington, D.C.,World Cancer Research Fund/American Institute for Cancer Research
Wu A, Paganini-Hill A, Ross R and Henderson B (1987) Alcohol, physical activity and other risk factors for colorectal cancer: a prospective study. Br J Cancer 55: 687–694
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Terry, P., Giovannucci, E., Bergkvist, L. et al. Body weight and colorectal cancer risk in a cohort of Swedish women: relation varies by age and cancer site. Br J Cancer 85, 346–349 (2001). https://doi.org/10.1054/bjoc.2001.1894
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DOI: https://doi.org/10.1054/bjoc.2001.1894
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