Abstract
To investigate if decreased exposure to common childhood infections is associated with risk of childhood acute lymphoblastic leukaemia (ALL) we conducted a case–control study of 1842 newly diagnosed and immunophenotypically defined cases of ALL under age 15, and 1986 matched controls in the US. Data regarding day care, sibship size and common childhood infections were obtained through parental interviews. Data were analysed stratified by leukaemia lineage and separately for ‘common’ childhood ALL (age 2–5 years, CD19, CD10-positive). Neither attendance at day care nor time at day care was associated with risk of ALL overall or ‘common’ ALL. Ear infections during infancy were less common among cases, with odds ratios of 0.86, 0.83, 0.71 and 0.69 for 1, 2–4, 5+ episodes, and continuous infections respectively (trend P = 0.026). No effect of sibship size or birth interval was seen. With one exception (ear infections), these data do not support the hypothesis that a decrease in the occurrence of common childhood infection increases risk of ALL. © 2000 Cancer Research Campaign
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References
Alexander FE, Chan LC, Lam TH, Yuen P, Leung NK, Ha SY, Yuen HL, Li CK, Li CK, Lau YL and Greaves MF (1997) Clustering of childhood leukaemia in Hong Kong: association with the childhood peak and common acute lymphoblastic leukaemia with population mixing. Br J Cancer 75: 457–463
Feychting M and Ahlbom A (1993) Magnetic fields and cancer in children residing near Swedish high-voltage power lines. Am J Epidemiol 138: 467–481
Greaves MF and Chan LC (1986) Is spontaneous mutation the major ‘Cause’ of childhood acute lymphoblastic leukaemia?. Br J Haematol 64: 1–13
Greaves MF (1988) Speculations on the cause of childhood acute lymphoblastic leukemia. Leukemia 2: 120
Greaves M (1993) A natural history for pediatric acute leukemia. Blood 82: 1043–1051
Greaves MF (1997) Aetiology of acute leukaemia. Lancet 349: 344–349
Gurney JG, Severson RK, Davis S and Robison LL (1995) Incidence of cancer in children in the United States. Cancer 75: 2186–2195
Hansen BWL (1993) Acute illnesses in children. Scand J Prim Health Care 11: 202–206
Haskins R and Kotch J (1986) Day care and illness: evidence, cost, and public policy. Pediatrics 77: 951–982
Hatch EE, Linet MS, Kleinerman RA, Tarone RE, Severson RK, Hartsock CT, Haines C, Kaune WT, Friedman D, Robison LL and Wacholder S (1988) Association between childhood acute lymphoblastic leukaemia and use of electrical appliances during pregnancy and childhood. Epidemiology 9: 234–245
James WH (1990) Further evidence for the hypothesis that one cause of childhood leukaemia is infection. Paediatr Perinat Epidemiol 4: 113–117
Kaye SA, Robison LL, Smithson WA, Gunderson P, King FL and Neglia JP (1991) Maternal reproductive history and birth characteristics in childhood acute lymphoblastic leukaemia. Cancer 68: 1351–1355
Kersey JH (1997) Fifty years of studies of the biology and therapy of childhood leukemia. Blood 90: 4243–4251
Kinlen LJ (1988) Evidence for an infective cause of childhood leukaemia: comparison of a Scottish New Town with nuclear reprocessing sites in Britain. Lancet ii: 1323–1327
Kinlen LJ (1995) Epidemiological evidence for an infective basis for childhood leukaemia. Br J Cancer 71: 1–5
Kinlen LJ, Clarke K and Hudson C (1990) Evidence from population mixing in British New Towns 1946–85 of an infective basis for childhood leukaemia. Lancet 336: 577–582
Kleinerman RA, Linet MS, Hatch EE, Wacholder S, Tarone RE, Severson RK, Kaune WT, Friedman DR, Haines CM, Muirhead CR, Boice JD Jr and Robison LL (1997) Magnetic field exposure assessment in a case–control study of childhood leukemia. Epidemiology 8: 575–583
Linet MS, Hatch EE, Kleinerman RA, Robison LL, Kaune WT, Friedman DR, Severson RK, Haines CM, Hartsock CT, Niwa S, Wacholder S and Tarone RE (1997) Residential exposure to magnetic fields and acute lymphoblastic leukemia in children. N Engl J Med 337: 1–7
Parkin DM, Kramarova E, Draper GJ, Masuyer E, Michaelis J, Neglia J, Qureshi S and Stiller CA (1998) International Incidence of Childhood Cancer. II: IARC Scientific Publication 144: IARC: Lyon
Petridou E, Kassimos D, Kalmanti M, Kosmidis H, Haidas S, Flyzani V, Tong D and Trichopoulos D (1993) Age of exposure to infections and risk of childhood leukaemia. Br Med J 307: 774
Pui C (1995) Childhood leukaemias. N Engl J Med 332: 1618–1630
Pui C, Behm FG and Crist WM (1993) Clinical and biologic relevance of immunologic marker studies in childhood acute lymphoblastic leukemia. Blood 82: 343–362
Reves RR, Morrow AL, Bartlett AV, Caruso CJ, Plumb RL, Lu BT and Pickering LK (1993) Child day care increases the risk of clinic visits for acute diarrhea and diarrhea due to rotavirus. Am J Epidemiol 137: 97–107
Robison LL and Daigle AE (1984) Control selection using random digit dialing for cases of childhood cancer. Am J Epidemiol 12: 164–166
Ross JA, Davies SM, Potter JD and Robison LL (1994) Epidemiology of childhood leukemia, with a focus on infants. Epidemiol Rev 16: 243–272
Sandler DP and Ross JA (1997) Epidemiology of acute leukemia in children and adults. Semin Oncol 24: 3–16
Savitz DA, Wachtel H, Barnes FA, John EM and Tvrdik JG (1988) Case-control study of childhood cancer and exposure to 60-Hz magnetic fields. Am J Epidemiol 128: 231–238
Smith M (1997) Considerations on a possible viral etiology for B-precursor acute lymphoblastic leukemia of childhood. J Immunother 20: 89–100
Wald ER, Guerra N and Byers C (1991) Upper respiratory tract infections in young children: duration and frequency of complications. Pediatrics 87: 129–133
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Neglia, J., Linet, M., Shu, X. et al. Patterns of infection and day care utilization and risk of childhood acute lymphoblastic leukaemia. Br J Cancer 82, 234–240 (2000). https://doi.org/10.1054/bjoc.1999.0905
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DOI: https://doi.org/10.1054/bjoc.1999.0905
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