Projections for the period 1995–2029 suggest that the number of men dying from mesothelioma in Western Europe each year will almost double over the next 20 years, from 5000 in 1998 to about 9000 around 2018, and then decline, with a total of about a quarter of a million deaths over the next 35 years. The highest risk will be suffered by men born around 1945–50, of whom about 1 in 150 will die of mesothelioma. Asbestos use in Western Europe remained high until 1980, and substantial quantities are still used in several European countries. These projections are based on the fit of a simple age and birth cohort model to male pleural cancer mortality from 1970 to 1989 for six countries (Britain, France, Germany, Italy, The Netherlands and Switzerland) which together account for three-quarters of the population of Western Europe. The model was tested by comparing observed and predicted numbers of deaths for the period 1990–94. The ratio of mesothelioma to recorded pleural cancer mortality has been 1.6:1 in Britain but was assumed to be 1:1 in other countries.
Brochard, P., Iwatsubo, Y., Pairon, J. C., Pierre, N., Boutin, C. & Bignon, J. (1995). Estimation of the pleural mesothelioma incidence in France based on the death certificates and the data of a case–control study (abstract), Third International Mesothelioma Conference: Creteil, FranceSeptember 1995
Cullen, M. R. (1998). Chrysotile asbestos: enough is enough. Lancet 351: 1377–1378.
Decarli, A., La Vecchia, C., Mezzanotte, G. & Cislaghi, C. (1987). Birth cohort, time and age effects in Italian cancer mortality. Cancer 59: 1221–1232.
Dement, J. M., Harris, R. L. Jr, Symons, M. J. & Shy, C. (1983a). Exposures and mortality among chrysotile asbestos workers. Part I: Exposure estimates. Am J Ind Med 4: 399–419.
Dement, J. M., Harris, R. L. Jr, Symons, M. J. & Shy, C. (1983b). Exposures and mortality among chrysotile asbestos workers. Part II: Mortality. Am J Ind Med 4: 421–433.
Doll, R. & Peto, J. (1985). Asbestos: Effects on Health of Exposure to Asbestos, Health and Safety Commission: HMSO: London
European Commission and Directorate-General for Industry (1996). Study on the Impact on the Internal Market of Community Legislation Limiting the Marketing and use of Asbestos, Environmental Resources Management: London
Health Effects Institute – Asbestos Research (1991). Asbestos in Public and Commercial Buildings: a Literature Review and Synthesis of Current Knowledge, Health Effects Institute: Cambridge MA, USA
Health and Safety Commission (1997). Health and Safety Statistics 1996/97, HSE Books: Sudbury
Hodgson, J. T., Peto, J., Jones, J. R. & Matthews, F. E. (1997). Mesothelioma mortality in Britain: patterns by birth cohort and occupation. Ann Occ Hyg 41: (suppl.1) 129–133.
International Programme on Chemical Safety (1998). Environmental Health Criteria 203: Chrysofile Asbestos, WHO: Geneva
La Vecchia, C., Lucchini, F., Negri, E., Boyle, P., Maisonneuve, P. & Levi, F. (1992). Trends of cancer mortality in Europe, 1955–1989: II, Respiratory tract, bone, connective and soft tissue sarcomas, and skin. Eur J Cancer 28: 514–599.
Liddell, F. D. K., McDonald, A. D. & McDonald, J. C. (1997). The 1891–1920 birth cohort of Quebec chrysotile miners and millers: development from 1904 and mortality to 1992. Ann Occup Hyg 41: 13–36.
McDonald, A. D., Case, B. W., Churg, A., Dufresne, A., Gibbs, G. W., Sebastien, P. & McDonald, J. C. (1997). Mesothelioma in Quebec chrysotile miners and millers: epidemiology and aetiology. Ann Occup Hyg 41: 707–719.
McDonald, A. D., Fry, J. S., Woolley, A. J. & McDonald, J. C. (1983). Dust exposure and mortality in an American chrysotile textile plant. Br J Ind Med 40: 361–367.
Office for National Statistics (1996). Mortality Statistics: Review of the Registrar General on Deaths by Cause, Sex and Age in England and Wales, 1993 (revised) and 1994, Series DH2 no. 21. HMSO: London
Office of Population Censuses and Surveys/Health and Safety Executive (1995). Occupational Health Decennial Supplement, Series DS no. 10. HMSO: London
Peto, J., Henderson, B. E. & Pike, M. C. (1981). Trends in mesothelioma incidence in the United States and the forecast epidemic due to asbestos exposure during World War II. In Quantification of Occupational Cancer, Banbury Report 9, Peto R and Schneiderman M (eds), pp. 51–69, Cold Spring Harbor Laboratory: Cold Spring Harbor, NY
Peto, J., Seidman, H. & Selikoff, I. J. (1982). Mesothelioma mortality in asbestos workers: implications for models of carcinogenesis and risk assessment. Br J Cancer 45: 124–135.
Peto, J., Hodgson, J. T., Matthews, F. E. & Jones, J. R. (1995). Continuing increase in mesothelioma mortality in Britain. Lancet 345: 535–539.
Peto, R., Lopez, A. D., Boreham, J., Thun, M. & Heath, C. (1994). Mortality from smoking in developed countries 1950–2000, Oxford University Press: Oxford
Price, B. (1996). Analyses of current trends in US mesothelioma incidence. Am J Epidemiol 145: 211–218.
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Peto, J., Decarli, A., Vecchia, C. et al. The European mesothelioma epidemic. Br J Cancer 79, 666–672 (1999). https://doi.org/10.1038/sj.bjc.6690105
- pleural cancer
- mortality trends
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