Table 4 Comparison of positivity rates for CTC detection in MBC

From: Circulating tumour cell detection: a direct comparison between the CellSearch System, the AdnaTest and CK-19/mammaglobin RT–PCR in patients with metastatic breast cancer

Reference Method Volume (ml) No. of patients No. of samples Positivity rate (% of samples)
Allard et al (2004) CellSearch 7.5 422 1316 37a
Cristofanilli et al (2004) CellSearch 7.5 177 NA 61a
Zieglschmid et al (2007a) AdnaGen 2 × 5 48 NA 69
Aktas et al (2009) AdnaGen 2 × 5 39 226 31
  1. Abbreviation: NA=not applicable.
  2. a Positivity rate defined as 2 or more CTC per 7.5 ml peripheral blood.