Table 2 Activity of pazopanib, sunitinib, and sorafenib against purified kinases

From: Myelosuppression and kinase selectivity of multikinase angiogenesis inhibitors

  Kiapp (n M)
Enzyme Pazopanib Sunitinib Sorafenib
VEGFR-1 15 229 10
VEGFR-2 8 51 4
VEGFR-3 10 30 6
PDGFR-α 30 28 2
PDGFR-β 14 7 5
c-Kit 2.4 0.45 15
Flt-3 230 0.6 22
  1. Abbreviations: Kiapp=apparent inhibition constant; PDGFR=platelet-derived growth factor receptor; VEGFR=vascular endothelial growth factor receptor.