Table 4 Expression of WFDC2 (HE4) and MUC16 (CA125) mRNA in tissue specimens of endometrium, non-ovarian and ovarian endometriosis, endometrial cancer, and ovarian cancer as log2 intensity values

From: Serum HE4 concentration differentiates malignant ovarian tumours from ovarian endometriotic cysts

   WFDC2 MUC16
Sample group N Median 25% 75% FC P -value a Median 25% 75% FC P -value a
E of healthy control 41 7.67 6.96 8.28    7.1 6.76 7.48   
E of endo patient 64 7.75 7.17 8.28 1.1b NSb 7.21 6.86 7.63 1.1b NSb
Non-ovarian endo 149 7.03 6.65 7.44 0.6b <0.05b 6.62 6.48 6.84 0.7b <0.05b
Ovarian endo 28 6.73 6.45 7.13    6.49 6.37 6.65   
EmCa 14 8.61 8.06 9.24 1.9b NS 6.28 6.14 7.29 0.6b <0.05b
OvCa 15 9.25 8.36 10.04 5.7c <0.05c 6.86 6.66 7.74 1.3c <0.05c
  1. E=endometrium; EmCA=endometrial cancer; endo=endometriosis; OvCa=ovarian cancer; NS=not significant.
  2. aDunn's method.
  3. bCompared to endometrium specimens of healthy controls.
  4. cCompared to ovarian endometriomas.