Table 3 Odds ratiosa and 95% confidence intervals for biliary tract cancer in relation to age at gallstone diagnosis and duration of stones, Shanghai, China

From: Gallstones and the risk of biliary tract cancer: a population-based study in China

  Controls b Controls c Gallbladder cancer Bile duct cancer Ampulla of Vater cancer
  n n n OR 95% CI n OR 95% CI n OR 95% CI
Total 959 902 368    191    68   
Duration of gallstones (years)
 No gallstones 735 735 60 1.0 64 1.0 32 1.0
1 74 70 138 24.5 16.4–36.5 63 10.2 6.6–15.7 20 6.5 3.5–12.1
 2–4 23 17 30 23.6 12.1–45.8 7 3.7 1.5–9.1 2 1.7 0.4–7.7
 5–9 47 30 35 14.9 8.5–26.2 11 2.9 1.4–5.9 5 2.4 1.9–6.5
10 80 50 90 23.3 15.0–36.3 37 5.6 3.5–9.0 4 1.1 1.4–3.2
Age at diagnosis of gallstones
 No gallstones 735 735 60 1.0 63 1.0 32 1.0
 <45 28 18 41 25.5 13.6–47.8 16 6.2 3.2–12.2 1 0.8 0.1–6.4
 45–59 82 53 82 19.2 12.4–29.7 42 6.0 3.8–9.4 9 2.6 1.2–5.6
60 114 96 173 24.0 16.2–35.6 62 7.2 4.7–11.1 21 4.2 2.3–7.8
Age at diagnosis of gallstones and duration of gallstones
 No gallstones 735 735 60 1.0 64 1.0 32 1.0  
 <55, 1 year 8 7 12 16.1 5.7–45.3 7 8.8 2.8–27.1 2 8.3 1.4–49.1
 <55, 2–5 years 2 2 5 22.1 4.1–120.3 2 9.3 1.3–68.7 1 16.5 1.3–204.3
 <55, 6 years 60 38 79 25.6 16.0–38.8 33 6.5 3.9–10.6 4 1.7 0.6–5.1
55, 1 year 66 63 126 25.4 16.7–38.8 56 10.3 6.6–16.2 18 6.8 3.5–12.9
55, 2–5 years 34 26 34 17.7 9.7–32.2 8 2.9 1.3–6.7 2 1.5 0.3–6.8
55, 6 years 54 31 37 16.8 9.4–30.0 12 2.8 1.4–5.6 4 1.7 0.6–5.2
  1. Adjusted for age, sex (if applicable), and education level.
  2. bIncluded all population controls. Bile duct cancer and ampulla of Vater cancer were compared with all population controls.
  3. cExcluded population controls with a history of cholecystectomy (n=55) or unknown history (N=2). Gallbladder cancer cases were compared with this group.