Table 3 Methotrexate-related toxicity

From: Carboxypeptidase G2 rescue in patients with methotrexate intoxication and renal failure

   CTC scale (number of patients ( n) (%))
Kind of toxicity Number of evaluable patients ( n) 0 1 2 3 4
Infection 40 27 (67.5) 1 (2.5) 7 (17.5) 1 (2.5) 4 (10.0)
Fever 38 26 (68.4) 3 (7.9) 8 (21.1) 1 (2.6) 0 (0)
Gastrointestinal       
 Vomiting 43 13 (30.2) 11 (25.6) 8 (18.6) 7 (16.3) 4 (9.3)
 Nausea 39 12 (30.8) 11 (28.2) 7 (17.9) 7 (17.9) 2 (5.1)
 Oral mucositis 39 17 (43.6) 9 (23.1) 7 (17.9) 6 (15.4) 0 (0)
 Diarrhoea 41 24 (58.5) 9 (22.0) 5 (12.2) 1 (2.4) 2 (4.9)
Skin 42 29 (69.0) 9 (21.4) 4 (9.5) 0 (0) 0 (0)
Haemorrhage 39 32 (82.1) 2 (5.1) 2 (5.1) 0 (0) 3 (7.7)
Kidney       
 Creatinine 41 7 (17.1) 7 (17.1) 13 (31.7) 9 (22.0) 5 (12.2)
 Creatinine clearance 25 6 (24.0) 5 (20.0) 4 (16.0) 5 (20.0) 5 (20.0)
 Proteinuria 31 21 (67.7) 5 (16.1) 3 (9.7) 1 (3.2) 1 (3.2)
 Haematuria 34 23 (67.6) 7 (20.6) 3 (8.8) 0 (0) 1 (2.9)
Liver       
 GOT/GPT 40 12 (30.0) 5 (12.5) 10 (25.0) 6 (15.0) 7 (17.5)
 Bilirubin 40 20 (50) 12 (0) 7 (17.5) 0 (0) 1 (2.5)
 Liver clinically 27 24 (88.9) 0 (0) 2 (7.4) 0 (0) 1 (3.7)
Lung 40 33 (82.5) 0 (0) 1 (2.5) 3 (7.5) 3 (7.5)
Heart/circulation       
 Cardiomyopathy 40 36 (90.0) 0 (0) 1 (2.5) 0 (0) 3 (7.5)
 Echocardiography 19 18 (94.7) 0 (0) 0 (0) 0 (0) 1 (5.3)
Neurotoxicity       
 Central 38 31 (81.6) 5 (13.2) 0 (0) 0 (0) 2 (5.3)
 Peripheral 38 31 (81.6) 6 (15.8) 0 (0) 0 (0) 1 (2.6)