Table 2 Characteristics of patients who got a second CPDG2 injection

From: Carboxypeptidase G2 rescue in patients with methotrexate intoxication and renal failure

Underlying disease Age (years) MTX level prior to first CPDG2 (μ M) Dose of first CPDG2 (U kg−1) Time after MTX start (h) MTX decrease (%) MTX level prior to-second CPDG2 (μ M) Dose of second CPDG2 (U kg−1) Time after MTX start (h) MTX decrease (%) Last MTX level ( μ M)
ALL 17.1 29.7 33 58 77 7.6 33 64 26.32 0.21
NHL 10.2a 45 45 143.5 91 3.1 22 192 69.86 3.4
NHL 55 62 47 34.2 84 9.7 47 48.2 8.25 0.07
Histiocytoma 39.4a 688 54 37.5 88 NA 54 39 NA 8.06
Osteosarcoma 15.4 306 46 63.4 74 13.4 46 84.4 (−) 26.12b 3.4
Osteosarcoma 27.9 138 36 34.5 94 8.9 55 124.5 43.82 0.1
Osteosarcoma 9.4 596 50 32 84 77.6 20 38 4.64 0.83
Osteosarcoma 19.1a 815 47 24.8 89 87.5 47 28.5 (−) 2.29b 25.49
Osteosarcoma 14.4 901 45 50.8 90 1.26 45 56 NA NA
  1. aPatient died.
  2. bNegative values are due to a rerise of the MTX concentration.
  3. NA=not available.