Table 3 Acute toxicity

From: Phase II study of radiotherapy combined with gemcitabine for locally advanced pancreatic cancer

Grade 1 (%) 2 (%) 3 (%) 4 (%)
Haematological toxicity
 Leucocytopenia 3 (7) 17 (40) 21 (50) 1 (2)
 Neutropenia 9 (21) 15 (36) 11 (26) 3 (7)
 Thrombcoytopenia 22 (52) 2 (5) 1 (2) 0 (0)
 Anaemia 21 (50) 17 (40) 0 (0) 1a (2)
Nonhaematological toxicity
 Total bilirubin 10 (24) 5 (12) 1 (2) 0 (0)
 AST 14 (33) 5 (12) 1 (2) 0 (0)
 ALT 15 (36) 11 (26) 4 (10) 0 (0)
 ALP 15 (36) 5 (12) 0 (0) 0 (0)
 Creatinine 0 (0) 0 (0) 0 (0) 0 (0)
 Anorexia 9 (21) 5 (12) 10 (24) 14 (33)
 Nausea 11 (26) 11 (26) 9 (21) 0 (0)
 Vomiting 10 (24) 7 (17) 0 (0) 0 (0)
 Diarrhoea 1 (2) 1 (2) 0 (0) 0 (0)
 Mucositis 0 (0) 0 (0) 0 (0) 0 (0)
 Duodenal ulcer 0 (0) 0 (0) 0 (0) 1a (2)
 Fatigue 17 (40) 14 (33) 2 (5) 0 (0)
 Skin rash 0 (0) 1 (2) 0 (0) 0 (0)
 Infection 0 (0) 0 (0) 0 (0) 1a (2)
  1. AST=aspartate aminotransferase; ALT=alanine aminotransferase; ALP=alkaline phosphatase.
  2. aOne patient died of duodenal bleeding and sepsis.