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Relative harms and merits of postoperative radiation following conservative surgery for low risk breast cancer

British Journal of Cancer volume 86, pages 310–311 (2002)Cite this article

Buchholz and Singletary raise the following issues in their commentary to our study (Holli et al, 2001):

  • the breast preservation rate should not have been reported as an endpoint as it was not predetermined by the protocol and, therefore, it is subject to bias

  • no aesthetic outcomes were reported

  • loco-regional recurrences are likely to be associated with distant metastases and an increased risk of death. Hence, longer follow-up after salvage therapy is needed.

the breast preservation rate should not have been reported as an endpoint as it was not predetermined by the protocol and, therefore, it is subject to bias

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References

  • Holli K, Saaristo R, Jsola J, Joensuch H, Hakama M (2001) Lumpectomy with or without postoperative radiotherapy for breast cancer with favourable prognostic features: results of a randomized study. Br J Cancer 84: 164–169

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Authors and Affiliations

  1. University Hospital, Palliative Medicine, PO Box 2000, Tampere, 33521, Finland

    K Holli, R Saaristo, J Isola, H Joensuu & M Hakama

Authors
  1. K Holli
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  2. R Saaristo
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  3. J Isola
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  4. H Joensuu
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  5. M Hakama
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Correspondence to K Holli.

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Holli, K., Saaristo, R., Isola, J. et al. Relative harms and merits of postoperative radiation following conservative surgery for low risk breast cancer. Br J Cancer 86, 310–311 (2002). https://doi.org/10.1038/sj.bjc.6600005

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  • DOI: https://doi.org/10.1038/sj.bjc.6600005

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