Table 2 Separation of clusters of 60 NCI cell lines obtained by hierarchical cluster analysis shown in Figure 1 in comparison to sensitivity to eight artemisinins

From: Microarray expression profiles of angiogenesis-related genes predict tumor cell response to artemisinins

  Cluster 1 Cluster 2 Cluster 3 c2 Test
ART     
 Sensitive 7 16 5  
 Resistant 12 15 0 P=0.0422
ARE     
 Sensitive 6 19 5  
 Resistant 14 15 0 P=0.0094
ARM     
 Sensitive 4 6 5  
 Resistant 14 27 0 P=0,0005
ARAB     
 Sensitive 7 17 4  
 Resistant 12 18 1 NS
ARTEMIS     
 Sensitive 6 13 4  
 Resistant 8 14 0 NS
ARTEST 1     
 Sensitive 5 20 5  
 Resistant 15 15 0 P=0.0047
ARTEST 2     
 Sensitive 6 19 4  
 Resistant 13 15 1 P=0.0885*
ARS     
 Sensitive 4 14 4  
 Resistant 13 20 1 P=0.0708*
  1. NS, not significant (P>0.05).
  2. *Borderline significant (0.05<P<0.1).
  3. The median IC50 values were used as cutoff thresholds to separate tumor cell lines as being ‘sensitive’ or ‘resistant’.