Table 1 Correlation of the IC50 values for artemisinin deriviatives to mRNA baseline expression of angiogenesis-related genes of 60 NCI cell lines by means of Kendall's τ test

From: Microarray expression profiles of angiogenesis-related genes predict tumor cell response to artemisinins

Symbol Genbank Name ART ARE ARM ARTEMIS ARTEST1 ARTEST2 ARAB ARS
MMP9 T41204 Matrix metalloproteinase 9 (gelatinase B, 92 kDa gelatinase, 92 kDa type IV collagenase) 0.00003 (−) 0.00190 (−) 0.00068 (−) 0.00003 (−) 0.00034 (−) 0.000002 (−) 0.03935 (−) NS
COL18A1 AA009987 Collagen, type XVII, alpha 1 0.00004 (+) 0.00766 (+) 0.02312 (+) 0.03095 (+) 0.00024 (+) 0.00035 (+) 0.03854 (+) NS
DVL3 W79440 Dishevelled, dsh homolog 3 (Drosophila) 0.00014 (+) 0.00005 (+) 0.00003 NS 0.00412 (+) 0.00587 (+) 0.01488 (+) 0.00003 (+)
F3 R34833 Coagulation factor III (thromboplastin, tissue factor) 0.00069 (+) 0.00269 (+) 0.01324 (+) 0.00390 (+) 0.00011 (+) 0.00226 (+) 0.00012 (+) NS
NID2 W70102 Nidogen 2 0.00101 (+) NS NS 0.00942 0.00381 (+) 0.00943 (+) 0.02725 (+) NS
HIF1A W47003 Hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.00234 (+) 0.00377 (+) 0.02504 0.00052 0.00072 (+) 0.00064 (+) 0.02062 (+) NS
PLAU AA040727 Plasminogen activator, urokinase 0.00259 (+) 0.02682 (+) NS 0.02244 (+) NS 0.03001 (+) 0.02579 (+) NS
MPDZ N71935 Multiple PDZ domain protein 0.00261 (+) 0.00896 (+) 0.02243 (+) 0.01214 (+) 0.00308 (+) 0.00204 (+) NS NS
PIN AA040248 Dynein, cytoplasmic, light polypeptide 0.00314 (+) 0.00217 (+) 0.00002 (+) 0.00939 (+) 0.00200 (+) 0.00117 (+) 0.00852 (+) NS
EFEMP1 AA030000 EGF-containing fibulin-like extracellular matrix protein 1 0.00475 (+) 0.00402 (+) NS 0.01110 (+) 0.00716 (+) 0.01558 (+) 0.00409 (+) NS
THBS1 AA056585 Thrombospondin 1 0.00501 (+) 0.00125 (+) 0.00617 (+) 0.01243 (+) 0.00354 (+) 0.00468 (+) 0.02598 (+) NS
NRCAM N59824 Neuronal cell adhesion molecule 0.00642 (+) 0.03943 (+) 0.01164 (+) 0.04543 (+) 0.00758 (+) 0.00026 (+) NS 0.03120 (+)
FN1 W15432 Fibronectin 1 0.00805 (−) 0.00096 (−) 0.00026 (−) 0.00698 (−) 0.02236 (−) 0.00537 (−) NS NS
COL4A2 AA056692 Collagen, type IV, alpha 2 0.00861 (+) 0.00549 (+) 0.02164 (+) 0.01835 (+) 0.00429 (+) 0.01024 (+) 0.01469 (+) NS
MMP11 AA034203 Matrix metalloproteinase 11 (stromelysin 3) 0.00861 (+) 0.02520 (+) NS 0.00627 (+) NS NS 0.00377 (+) 0.00617 (+)
VEGFC N94399 Vascular endothelial growth factor C 0.00904 (+) 0.00556 (+) NS 0.02154 0.00193 (+) 0.03038 (+) NS NS
EFEMP1 AA040443 EGF-containing fibulin-like extracellular matrix protein 1 0.01091 (+) 0.01866 (+) NS 0.00384 (+) 0.01118 (+) 0.01455 (+) 0.00130 (+) NS
BMP1 AA029677 Bone morphogenetic protein 1 0.01261 (−) 0.01293 (−) 0.00081 (−) NS 0.02750 (−) NS 0.00891 (−) NS
GJA4 W69079 Gap junction protein, alpha 4, 37 kDa (connexin 37) 0.01601 (+) 0.00121 (+) 0.00485 0.04128 0.00468 (+) 0.04392 (+) 0.00112 (+) 0.02429 (+)
CYR61 AA044574 Cysteine-rich, angiogenic inducer, 61 0.01899 (+) 0.00309 (+) 0.01505 (+) NS 0.00153 (+) NS 0.00344 (+) NS
IL6ST H85457 Interleukin 6 signal transducer (gp130) 0.02258 (+) 0.00145 (+) 0.01198 (+) 0.06538 (+) 0.01309 (+) 0.01425 (+) 0.0093 (+) NS
ANG AA011614 Angiogenin, ribonuclease, RNAse A family 5 0.02351 (−) 0.02121 (−) NS 0.01989 (−) 0.00661 (−) NS NS NS
ABCG1 H68928 ATP-binding cassette, sub-family G (WHITE), member 1 0.02711 (−) 0.01101 (−) NS 0.04098 (−) 0.00367 (−) 0.04254 (−) 0.04903 (−) 0.02047 (−)
NOS2A H67843 Nitric oxide synthase 2A 0.02778 (−) 0.03632 (−) 0.00374 (−) NS NS NS NS 0.02999 (−)
BMPR2 H96519 Bone morphogenetic protein receptor, type II 0.03001 (+) 0.04112 (+) 0.00055 0.00085 0.00070 (+) 0.03235 (+) 0.03564 (+) NS
EphA2 AA001368 Ephrin A2 0.03267 (+) 0.00416 (+) 0.00224 (+) 0.00003 (+) 0.00340 (+) 0.03122 (+) 0.00018 (+) NS
AXL T91043 AXL receptor tyrosine kinase RNA 0.03293 (+) 0.00391 (+) 0.02079 (+) 0.03474 (+) 0.00852 (+) 0.01689 (+) 0.00341 (+) NS
TFPI2 AA017446 Tissue factor pathway inhibitor 2 0.03391 (+) 0.04647 (+) NS NS 0.01032 (+) NS 0.00262 (+) NS
TGFB2 N48082 Transforming growth factor, beta 2 RNA 0.03503 (+) 0.00846 (+) 0.00910 (+) 0.02826 (+) 0.00176 (+) 0.00044 (+) 0.0393 (+) NS
FGF2 W52295 Fibroblast growth factor 2 (basic) 0.03539 (+) 0.01009 (+) 0.01959 NS NS NS 0.00005 (+) NS
COL1A2 AA056542 Collagen, type I, alpha 2 0.03744 (+) 0.00215 (+) 0.01827 (+) NS 0.04193 (+) NS NS NS
FGF2 W44678 Fibroblast growth factor 2 (basic) 0.04112 (+) 0.00138 (+) 0.01933 NS 0.03539 (+) NS 0.00009 (+) NS
  1. Abbreviations: ARAB, arteanuine B; ARS, artemisinin; ART, artesunate; ARE, arteether; ARM, artemether; ARTEMIS, artemisetene; ARTEST 1/2, dihydroartemisinylester stereoisomer 1/2.
  2. (+), high mRNA expression correlates with high IC50 values (direct correlation).
  3. (−), high mRNA expression correlates with low IC50 values (inverse correlation).
  4. NS, not significant (P>0.05).