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Linkage disequilibrium and association with methamphetamine dependence/psychosis of μ-opioid receptor gene polymorphisms

The Pharmacogenomics Journal volume 6, pages 179–188 (2006)Cite this article

Abstract

Several studies indicate that the μ-opioid receptor plays a role in addiction not only to opiate drugs but also to alcohol and non-opiate addictive drugs. Our studies aim to reveal the associations between gene polymorphisms and methamphetamine (MAP) dependence/psychosis. We newly identified several polymorphisms and four substantial linkage disequilibrium (LD) blocks in the μ-opioid receptor (OPRM1) gene. We found significant differences in both genotype and allele frequencies of the single-nucleotide polymorphism (SNP) IVS2+G691C between control (n=232) and MAP-dependent/psychotic patients (n=128). There was also a significant association between IVS2+G691C and patients with transient psychosis. These results suggest that the OPRM1 gene variations may be a factor in development and prognosis of MAP psychosis.

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Acknowledgements

We are grateful to the Japanese Ministry of Health, Labour and Welfare (MHLW) as well as to the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) for support in part by Grants MHLW13-040, MHLW15-7, MHLW17-pharmaco-001, MEXT15025206 and MEXT15029204.

Author information

Authors and Affiliations

  1. Division of Psychobiology, Tokyo Institute of Psychiatry, Tokyo, Japan

    S Ide, H Kobayashi, K Tanaka, H Shen, K Ikeda & I Sora

  2. Department of Pharmaceutical Sciences, Laboratory of Neuropharmacology, Hiroshima International University, Kure, Japan

    S Ide

  3. Department of Molecular Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan

    S Ide & M Satoh

  4. Department of Psychobiology, Tohoku University Graduate School of Medicine, Sendai, Japan

    H Kobayashi & I Sora

  5. Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

    H Ujike

  6. Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan

    N Ozaki

  7. Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan

    Y Sekine

  8. Department of Psychiatry, Teikyo University, School of Medicine, Ichihara Hospital, Chiba, Japan

    T Inada

  9. Department of Neuropsychiatry, Kurume University School of Medicine, Kurume, Japan

    M Harano

  10. Division of Psychiatry, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Tokyo, Japan

    T Komiyama

  11. Department of Psychogeriatrics, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan

    M Yamada

  12. Department of Psychiatry, Graduate School of Medicine, Chiba University, Chiba, Japan

    M Iyo

  13. Department of Psychiatry, Fujita Health University School of Medicine, Aichi, Japan

    N Iwata

  14. Health Administration Center, Azabu University, Kanagawa, Japan

    K Iwahashi

  15. Schizophrenia Research Project, Tokyo Institute of Psychiatry, Tokyo, Japan

    M Itokawa

  16. Department of Pharmacology, Hokkaido University Graduate School of Pharmaceutical Sciences, Sapporo, Japan

    M Minami

  17. Japanese Genetics Initiative for Drug Abuse (JGIDA), Japan

    H Ujike, N Ozaki, Y Sekine, T Inada, M Harano, T Komiyama, M Yamada, M Iyo, N Iwata & I Sora

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  1. S Ide
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  2. H Kobayashi
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Correspondence to I Sora.

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Ide, S., Kobayashi, H., Ujike, H. et al. Linkage disequilibrium and association with methamphetamine dependence/psychosis of μ-opioid receptor gene polymorphisms. Pharmacogenomics J 6, 179–188 (2006). https://doi.org/10.1038/sj.tpj.6500355

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  • DOI: https://doi.org/10.1038/sj.tpj.6500355

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