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Linkage analysis of smoking initiation and quantity in Dutch sibling pairs

The Pharmacogenomics Journal volume 4, pages 274–282 (2004)Cite this article

A Corrigendum to this article was published on 20 September 2004

Abstract

The heritability of smoking initiation (SI) and number of cigarettes smoked (NC) was determined in 3657 Dutch twin pairs. For SI a heritability of 36% was found and for NC of 51%. Both SI and NC were also significantly influenced by environmental factors shared by family members. The etiological factors that influence these traits partly overlap. Linkage analyses were performed on data of 536 DZ twins and siblings from 192 families, forming 592 sibling pairs. Results suggested QTLs on chromosome 6 (LOD=3.05) and chromosome 14 (LOD=1.66) for SI and on chromosome 3 (LOD=1.98) for NC. Strikingly, on chromosome 10 a peak was found in the same region for both SI (LOD=1.92) and for NC (LOD=2.29) which may partly explain the overlapping etiological factors for SI and NC.

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Acknowledgements

This work was supported by the Netherlands Organization for Scientific Research (NWO 985-10-002 and NWO 904-61-090) and ZonMW/NIDA (3100.0038). The work reported on here was supported in part by the Virginia Tobacco Settlement Foundation (Contract #8520012) through the Virginia Youth Tobacco Project, Virginia Commonwealth University and grants DA-11287 and MH-01458 from the United States National Institutes of Health. Genotyping was carried out by the Center for Medical Genetics in Marshfield (research.marshfieldclinic.org/genetics/). We would like to thank E Suchiman and N Lakenberg for DNA isolation and sample preparation and B Neale for assistance with the linkage analyses using Merlin.

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Authors and Affiliations

  1. Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands

    J M Vink, A L Beem, D Posthuma, G Willemsen & D I Boomsma

  2. Departments of Psychiatry and Human Genetics, Virginia Institute for Psychiatry and Behavioral Genetics, Medical College of Virginia of Virginia Commonwealth University, Richmond, VI, USA

    M C Neale & K S Kendler

  3. Section Molecular Epidemiology, Sylvius Laboratory, Leiden Universitary Medical Centre, Leiden, The Netherlands

    P E Slagboom

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  1. J M Vink
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Correspondence to J M Vink.

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Vink, J., Beem, A., Posthuma, D. et al. Linkage analysis of smoking initiation and quantity in Dutch sibling pairs. Pharmacogenomics J 4, 274–282 (2004). https://doi.org/10.1038/sj.tpj.6500255

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