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Investigation of polymorphism in the MDR1 gene and antidepressant-induced mania

The Pharmacogenomics Journal volume 3, pages 297–299 (2003)Cite this article

ABSTRACT

The involvement of the multi-drug-resistant 1 P-glycoprotein gene (MDR1 P-gp) in the transport of antidepressants across the blood–brain barrier makes it a good candidate for the prediction of antidepressant response and side effects. We investigated the role of the MDR1 P-gp gene in predicting the induction of mania in bipolar patients (BP) treated with proserotonergic drugs. Participants met the DSM-IV criteria for BP or BPII and had at least one depressive episode treated with proserotonergic antidepressants. The first group (n=26) included patients with at least one DSM-IV manic/hypomanic episode developed during antidepressant treatment; the second group (N=29) included patients with no antidepressant-induced switches. The common polymorphism of the MDR1 was genotyped for both groups and comparison was made with respect to the presence/absence of induced mania between the two groups. No association between antidepressant-induced mania and the MDR1 alleles or genotypes was found (χ2=1.85, 2 df, P=0.39; χ2=0.13, 1 df, P=0.72).

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Authors and Affiliations

  1. Department of Psychiatry, Neurogenetics Section, University of Toronto, Centre for Addiction and Mental Health, Toronto, Ontario, Canada

    V De Luca, E Mundo, J Trakalo, G W H Wong & J L Kennedy

  2. Dipartimento di Scienze Cliniche ‘Luigi Sacco', Cattedra di Psichiatria, Universita’ di Milano, Italy

    E Mundo

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Correspondence to J L Kennedy.

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De Luca, V., Mundo, E., Trakalo, J. et al. Investigation of polymorphism in the MDR1 gene and antidepressant-induced mania. Pharmacogenomics J 3, 297–299 (2003). https://doi.org/10.1038/sj.tpj.6500196

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