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Pharmacoproteomics in drug development

The Pharmacogenomics Journal volume 3, pages 69–76 (2003)Cite this article

ABSTRACT

The field of proteomics is taking on increased significance as the relevance of investigating and understanding protein expression in disease and drug development is appreciated. Recent advances in proteomics have been driven by the availability of numerous annotated whole-genome sequences and a broad range of technological and bioinformatic developments that underscore the complexity of the proteome. This review briefly addresses some of the various technologies that comprise Expression Proteomics and Functional Proteomics, citing examples where these emerging approaches have been applied to pharmacology, toxicology, and the development of drugs.

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Acknowledgements

We gratefully acknowledge the critical reading of the manuscript by Drs Mu Wang, Junyu Li, and Bob LeBoeuf.

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  1. Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN, USA

    Frank A Witzmann

  2. Corporate Research-Biotechnology Division, The Procter & Gamble Company, Cincinnati, OH, USA

    Raymond A Grant

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Correspondence to Frank A Witzmann.

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Witzmann, F., Grant, R. Pharmacoproteomics in drug development. Pharmacogenomics J 3, 69–76 (2003). https://doi.org/10.1038/sj.tpj.6500164

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