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References
Permutt MA, Hattersley A . Searching for type 2 diabetes genes in the post genome era Trends Endocrinol Metab 2000 11: 383–393
Yamagata K, Furuta H, Oda N, Kaisaki PJ, Menzel S, Cox NJ et al . Mutations in the hepatocyte nuclear factor-4α gene in maturity-onset diabetes of the young Nature 1996 384: 458–460
Vionnet N, Stoffel M, Takeda J, Yasuda K, Bell GI, Zouali H et al . Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus Nature 1992 356: 721–722
Yamagata K, Oda N, Kaisaki PJ, Menzel S, Furuta H, Vaxillaire M et al . Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young Nature 1996 384: 455–458
Stoffers DA, Ferrer J, Habener JF . Early-onset-type-II diabetes mellitus (MODY4) linked to IPF1 Nat Genet 1997 15: 106–110
Horikawa Y, Iwasaki N, Hara M, Furuta H, Hinokio Y, Cockburn BN et al . Mutation in hepatocyte nuclear factor-1β gene (TCF2) associated with MODY Nat Genet 1997 17: 384–385
Malecki MT, Jhala US, Antonellis A, Fields L, Doria A, Orban T et al . Mutations in NEURODI are associated with the development of type 2 diabetes mellitus Nat Genet 1999 23: 323–328
Taylor SI, Cama A, Accili D, Barbetti F, Quon MJ, de la Luz Sierra M et al . Mutations in the insulin receptor gene Endocrine Rev 1992 13: 566–595
Deeb SS, Fajas L, Nemoto M, Pihlajamaki J, Mykkanen L, Kuusisto J et al . A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity Nat Genet 1998 20: 284–287
Altshuler D, Hirschhorn JN, Klannemark M, Lindgren CM, Vohl MC, Nemesh J et al . The common PPARγ Prol12Ala polymorphism is associated with decreased risk of type 2 diabetes Nat Genet 2000 26: 76–80
Kubota N, Terauchi Y, Miki H, Tamemoto H, Yamauchi T, Komeda K et al . PPARγ mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance Mol Cell 1999 4: 597–609
Yamauchi T, Kamon J, Waki H, Murakami K, Motojima K, Komeda K et al . The mechanisms by which both heterozygous PPARgamma deficiency and PPARgamma agonist improve insulin resistance J Biol Chem 2001 276: 41245–41254
Yamauchi T, Waki H, Kamon J, Murakami K, Motojima K, Komeda K et al . Inhibition of RXR and PPARγ ameliorates diet-induced obesity and type 2 diabetes J Clin Invest 2001 108: 1001–1013
Almind K, Inoue G, Pedersen O, Kahn CR . A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin singaling J Clin Invest 1996 97: 2569–2575
Porzio O, Federici M, Hribal ML, Lauro D, Accili D, Lauro R et al . The Gly972->Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic β-cells J Clin Invest 1999 104: 357–364
Hribal ML, Federici M, Porzio O, Lauro D, Borboni P, Accili D et al . The Gly->Arg972 amino acid polymorphism in IRS-1 affects glucose metabolism in skeletal muscle cells J Clin Endocrinol Metab 2000 85: 2004–2013
Stumvoll M, Fritsche A, Volk A, Stefan N, Madaus A, Maeker E et al . The Gly972Arg polymorphism in the insulin receptor substrate-1 gene contributes to the variation in insulin secretion in normal glucose-tolerant humans Diabetes 2001 50: 882–885
Federici M, Hribal ML, Ranalli M, Marselli L, Porzio O, Lauro D et al . The common Arg972 polymorphism in insulin receptor substrate-1 causes apoptosis of human pancreatic islets FASEB J 2001 15: 22–24
Inoue H, Ferrer J, Welling CM, Elbein SC, Hoffman M, Mayorga R et al . Sequence variants in the sulfonylurea receptor (SUR) gene are associated with NIDDM in Caucasians Diabetes 1996 45: 825–831
Hansen T, Echwald SM, Hansen L, Moller AM, Almind K, Clausen JO et al . Decreased tolbutamide-stimulated insulin secretion in healthy subjects with sequence variants in the high-affinity sulfonylurea receptor gene Diabetes 1998 47: 598–605
Risch NJ . Searching for genetic determinants in the new millennium Nature 2000 405: 847–856
Zhang CY, Baffy G, Perret P, Krauss S, Peroni O, Grujic D et al . Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β cell dysfunction, and type 2 diebetes Cell 2001 105: 745–755
Esterbauer H, Schneitler C, Oberkofler H, Ebenbichler C, Paulweber B, Sandhofer F et al . A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans Nat Genet 2001 28: 178–183
Stuart JA, Harper JA, Brindle KM, Jekabsons MB, Brand MD . Physiological levels of mammalian uncoupling protein 2 do not uncouple yeast mitochondria J Biol Chem 2001 276: 18633–18639
Byrne MM, Sturis J, Menzel S, Yamagata K, Fajans SS, Dronsfield MJ et al . Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes susceptibility gene MODY3 on chromosome 12 Diabetes 1996 45: 1503–1510
Sovik O, Njolstad P, Folling I, Sagen J, Cockburn BN, Bell GI . Hyperexcitability to sulphonylurea in MODY3 Diabetologia 1998 41: 607–608
Pearson ER, Liddell WG, Shepherd M, Corrall RJ, Hattersley AT . Sensitivity to sulphonylureas in patients with hepatocyte nuclear factor-1 alpha gene mutations: evidence for pharmacogenetics in diabetes Diabet Med 2000 17: 543–545
Hanis CL, Boerwinkle E, Chakraborty R, Ellsworth DL, Concannon P, Stirling B et al . A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2 Nat Genet 1996 13: 161–166
Cox NJ, Frigge M, Nicolae DL, Concannon P, Hanis CL, Bell GI et al . Loci on chromosome 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans Nat Genet 1999 21: 213–215
Horikawa Y, Oda N, Cox NJ, Li X, Ortho-Melander M, Hara M et al . Genetic variations in the gene encoding calpain-10 is associated with type 2 diabetes mellitus Nat Genet 2000 26: 163–175
Baier LJ, Permana PA, Yang X, Pratley RE, Hanson RL, Shen G-Q et al . A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance J Clin Invest 2000 106: R69–R73
Patel YM, Lane DM . Role of calpain in adipocytes differentiation Proc Natl Acad Sci USA 1999 96: 1279–1285
Smith LK, Rice KM, Garner CW . The insulin-induced down-regulation of IRS-1 in 3T3-L1 adipocytes is mediated by a calcium-dependent thiol protease Mol Cell Endocrinol 1996 122: 81–92
Sreenan SK, Zhou Y-P, Otani K, Hansen PA, Currie KPM, Pan C-Y et al . Calpains play a role in insulin secretion and action Diabetes 2001 50: 2013–2020
Hanson RL, Ehm MG, Pettitt DJ, Prochazka M, Thompson DB, Timberlake D et al . Anautosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians Am J Hum Genet 1998 63: 1130–1138
Wiltshire S, Hattersley AT, Hitman GA, Walker M, Levy JC, Sampson M et al . A genomewide scan for loci predisposing to type 2 diabetes in a UK population (the Diabetes UK Warren 2 repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q Am J Hum Genet 2001 69: 553–569
Duggirala R, Blangero J, Almasy L, Dyer TD, Williams KL, Leach RJ et al . Linkage of type 2 diabetes mellitus and of age at onset to a genetic location on chromosome 10 q in Mexican Americans Am J Hum Genet 1999 64: 1127–1140
Mahtani MM, Wide'n E, Lehto M, Thomas J, McCarthy M, Brayer J et al . Mapping of a gene for NIDDM associated with an insulin secretion defect by a genome scan in Finnish families Nat Genet 1996 14: 90–95
Ghosh S, Watanabe RM, Hauser ER, Valle T, Magnuson VL, Erdos MR et al . Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs Proc Natl Acad Sci USA 1999 96: 2198–2203
Vionnet N, Hani El-H, Dupont S, Gallina S, Francke S, Dotte S . et al. Genome-wide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21–q24 Am J Hum Genet 2000 67: 1470–1480
Comuzzie AG, Funahashi T, Sonnenberg G, Martin LJ, Jacob HJ, Black AE et al . The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome J Clin Endocrinol Metab 2001 86: 4321–4325
Statnick MA, Beavers LS, Conner LJ, Corominola H, Johnson D, Hammond CD et al . Decreased expression of apM1 in omental and subcutaneous adipose tissue of humans with type 2 diabetes Int J Exp Diabetes Res 2000 1: 81–88
Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J et al . Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity Biochem Biophys Res Commun 1999 257: 79–83
Weyer C, Funahashi T, Tanaka S, Hotta K, Matsuzawa Y, Pratley RE et al . Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia J Clin Endocrinol Metab 2001 86: 1930–1935
Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K et al . The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity Nature Med 2001 7: 941–946
Berg AH, Combs TP, Du X, Brownlee M, Scherer PE . The adipocyte-secreted protein Acrp 30 enhances hepatic insulin action Nature Med 2001 7: 947–953
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Sesti, G. Searching for type 2 diabetes genes: prospects in pharmacotherapy. Pharmacogenomics J 2, 25–29 (2002). https://doi.org/10.1038/sj.tpj.6500078
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DOI: https://doi.org/10.1038/sj.tpj.6500078
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