PubMed, Web of Science, ScienceDirect, Chinese Biological Medical Literature Database, Chinese Wanfang Database, Chinese National Knowledge Infrastructure and reference lists of key publications. Language restrictions were placed with inclusion of English and Chinese texts only. No date restrictions were applied.
Original population-based studies that described the diagnostic criteria of MIH and provided prevalence data or sufficient information that could be used to calculate MIH prevalence.
Data extraction and synthesis
Two reviewers independently extracted the data. Meta-regression was done using a random effects model for parameters of age, gender and region. Heterogeneity was assessed using I2 statistic.
Seventy studies were included that encompassed a total of 89,520 people and 10,823 cases of MIH. The pooled global prevalence of MIH was 14.2% (95% CI 12.6-15.8), with South America having the highest prevalence (18%; 95% CI 13.8-22.2) and Africa the lowest (10.9%; 95% CI 4.2-17.6). There was no significant difference between male and female participants. Prevalence of MIH amongst children ten years of age or younger (15.1%, 95% CI 12.1-18.2) was higher than older children (12.1%, 95% CI 8.0-16.3).
This meta-analysis showed the average global prevalence of MIH as 14.2%. Some geographic regions had higher than average prevalence, which could inform oral health policy in those areas.
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Weerheijm KL . Molar incisor hypomineralisation (MIH). Eur J Paediatr Dent 2003; 4:114–120.
Mahoney E, Ismail FS, Kilpatrick N, Swain M . Mechanical properties across hypomineralized/hypoplastic enamel of first permanent molar teeth. Eur J Oral Sci 2004; 112:497–502.
Garg N, Jain AK, Saha S, Singh J . Essentiality of early diagnosis of molar incisor hypomineralization in children and review of its clinical presentation, Etiology and Management. Int J Clin Pediatr Dent 2012; 5:190–196.
Silva MJ, Scurrah KJ, Craig JM, Manton DJ, Kilpatrick N . Etiology of molar incisor hypomineralization - A systematic review. Community Dent Oral Epidemiol 2016; 44:342–353.
Teixeira RJPB, Andrade NS, Queiroz LCC, et al. Exploring the association between genetic and environmental factors and molar incisor hypomineralization: evidence from a twin study. Int J Paediatr Dent 2018; 28:198–206.
Lygidakis NA . Treatment modalities in children with teeth affected by molar-incisor enamel hypomineralisation (MIH): A systematic review. Eur Arch Paediatr Dent 2010; 11:65–74.
Schwendicke F, Elhennawy K, Reda S, Bekes K, Manton DJ, Krois J . Global burden of molar incisor hypomineralization. J Dent 2018; 68:10–18.
Address for correspondence: Dr Ye-Huan Sun, Department of Epidemiology and Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei, Anuhui 230032, China. E-mail: email@example.com
Zhao D, Dong B, Yu D, Ren Q, Sun Y. The prevalence of molar incisor hypomineralization: evidence from 70 studies. Int J Paediatr Dent 2018; 28: 170–179.
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Dave, M., Taylor, G. Global prevalence of molar incisor hypomineralisation. Evid Based Dent 19, 78–79 (2018). https://doi.org/10.1038/sj.ebd.6401324
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