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The impact of CD14 polymorphisms on the development of soluble CD14 levels during infancy

Genes & Immunity volume 7, pages 77–80 (2006)Cite this article

Abstract

CD14 is a receptor involved in the recognition of lipopolysaccharide and other bacterial wall components that may be involved in the balance between infectious and allergic disease and the early polarization towards TH1. Our group has shown an association between polymorphisms in the 5′ flanking region of the CD14 gene and plasma soluble CD14 (sCD14) levels at 11 years of age. However, whether this association is present at birth and in infancy remains to be determined. In this study, we measured sCD14 levels in plasma from the umbilical cord (n=387) and at 3 months (n=357) and 1 year (n=312) of age in non-selected healthy infants to assess their relationship with CD14 genotypes at −4190, −2838, −1720 and −260 (relative to translation start site). There was no relation of CD14 genotypes with sCD14 at birth. However, there was a significant association between CD14 genotypes and sCD14 as early as 3 months. Longitudinal analysis suggests that CD14 polymorphisms modulate sCD14 levels up to 1 year of age. This association early in life may have an impact on TH1 polarization and subsequent protection against allergic disease.

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Acknowledgements

This study was financially supported by Grants AI42268 and ES-00386 from the National Institutes of Health.

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Authors and Affiliations

  1. Department of Medicine, University of Arizona, Tucson, AZ, USA

    T D LeVan & W Klimecki

  2. Mel and Enid Zuckerman Arizona College of Public Health, University of Arizona, Tucson, AZ, USA

    S Guerra

  3. Arizona Respiratory Center, University of Arizona, Tucson, AZ, USA

    M M Vasquez & I C Lohman

  4. Department of Pediatrics, University of Arizona, Tucson, AZ, USA

    F D Martinez & A L Wright

  5. Department of Pharmacology, University of Arizona, Tucson, AZ, USA

    M Halonen

Authors
  1. T D LeVan
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  2. S Guerra
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  3. W Klimecki
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  4. M M Vasquez
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  5. I C Lohman
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  6. F D Martinez
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  7. M Halonen
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  8. A L Wright
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Correspondence to A L Wright.

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LeVan, T., Guerra, S., Klimecki, W. et al. The impact of CD14 polymorphisms on the development of soluble CD14 levels during infancy. Genes Immun 7, 77–80 (2006). https://doi.org/10.1038/sj.gene.6364276

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  • DOI: https://doi.org/10.1038/sj.gene.6364276

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