Differential susceptibility of A/J and B6 mice to systemic candidiasis. A/J and B6 mice were infected i.v. with a low dose (5 × 104) of C. albicans blastospores. (a) The number of colony-forming units (CFU) was determined in the brain, heart, kidney, liver, lung, and spleen of three mice of each strain 48 h postinjection. Fungal loads in the brain, heart, and kidney of A/J mice were significantly higher than in B6 at this time point. (b) Serum cytokine levels in 4–6 mice of each strain were also measured prior to infection and at the 48 h time point, as described in Materials and methods. TNF-α and IL-6 levels were significantly higher in A/J mice compared to B6. The standard error of the mean (s.e.m.) is indicated for each group. Statistically significant differences are indicated on the graphs (*P<0.05; **P<0.01; ***P<0.001).