Table 1 Distribution of alleles and genotypes for the PTPN22 1858C/T polymorphism in patients with generalised vitiligo and in control subjects

From: A single-nucleotide polymorphism in the gene encoding lymphoid protein tyrosine phosphatase (PTPN22) confers susceptibility to generalised vitiligo

  Controls Vitiligo a P-value OR (95% CI) Vitiligo b P-value OR (95% CI)
  (n=304) (n=165)    (n=113)   
Allele        
 C 556 (91.4%) 282 (85.5%)    191 (84.5%)   
 T 52 (8.6%) 48 (14.5%) 0.006c 1.82 (1.17–2.82) 35 (15.5%) 0.005c 1.96 (1.21–3.18)
Genotype        
 CC 254 (83.6%) 122 (74.0%)    83 (73.5%)   
 CT 48 (15.8%) 38 (23.0%)    25 (22.1%)   
 TT 2 (0.7%) 5 (3.0%) 0.005d   5 (4.4%) 0.005d  
  1. aVitiligo patient group with and without an autoimmune disorder.
  2. bVitiligo patients without an autoimmune disorder.
  3. cPatients vs controls using a 2 × 2 contingency table.
  4. dPatients vs controls using a 3 × 2 contingency table.
  5. OR, odds ratio; 95% CI, 95% confidence intervals.