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Intergenomic consensus in multifactorial inheritance loci: the case of multiple sclerosis

Genes & Immunity volume 5, pages 615–620 (2004)Cite this article

Abstract

Genetic linkage and association studies define chromosomal regions, quantitative trait loci (QTLs), which influence the phenotype of polygenic diseases. Here, we describe a global approach to determine intergenomic consensus of those regions in order to fine map QTLs and select particularly promising candidate genes for disease susceptibility or other polygenic traits. Exemplarily, human multiple sclerosis (MS) susceptibility regions were compared for sequence similarity with mouse and rat QTLs in its animal model experimental allergic encephalomyelitis (EAE). The number of intergenomic MS/EAE consensus genes (295) is significantly higher than expected if the animal model was unrelated to the human disease. Hence, this approach contributes to the empirical evaluation of animal models for their applicability to the study of human diseases.

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Acknowledgements

We thank Michael O Glocker, Michael Kreutzer, Gertrud Fischer, Brigitte Müller-Hilke and Claudia Voigt for their support. The developers of EnsEMBL are thanked for their extraordinary efforts. This work was supported by the BMBF projects FKZ 01GG9831, 01GG9841 and NBL3 (FKZ 01ZZ0108).

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Authors and Affiliations

  1. Institute of Immunology, University of Rostock, Schillingallee 70, Rostock, Germany

    P Serrano-Fernández, S M Ibrahim, H-J Thiesen & S Möller

  2. Institute of Neurology, University of Rostock, Gehlsheimer Straße 20, Rostock, Germany

    U K Zettl

  3. Department of Human Genetics, University of Bochum, Bochum, Germany

    R Gödde & J T Epplen

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  1. P Serrano-Fernández
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Correspondence to P Serrano-Fernández.

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Supplementary Information accompanies the paper on Genes and Immunity website (http://www.nature.com/gene).

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Serrano-Fernández, P., Ibrahim, S., Zettl, U. et al. Intergenomic consensus in multifactorial inheritance loci: the case of multiple sclerosis. Genes Immun 5, 615–620 (2004). https://doi.org/10.1038/sj.gene.6364134

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