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Toll-like receptor 6 gene (TLR6): single-nucleotide polymorphism frequencies and preliminary association with the diagnosis of asthma

Genes & Immunity volume 5, pages 343–346 (2004)Cite this article

Abstract

Toll-like receptor 6 (TLR6) is one of a series of highly conserved innate immune receptors. We resequenced TLR6 in DNA samples from 24 African Americans, 23 European Americans, and 24 Hispanic Americans, identifying 53 SNPs, 22 with an allele frequency >5%. Significant differences in SNP frequencies among the three populations were noted. In all, 11 SNPs caused amino-acid changes, including one with a frequency >5% in all three populations. Utilizing this SNP (Ser249Pro), we performed exploratory nested case–control disease-association studies, including one involving 56 African Americans with asthma and 93 African American controls. The minor allele of this SNP was associated with decreased risk for asthma (odds ratio 0.38, 95% CI 0.16–0.87, P=0.01), an effect consistent with the known biology of the toll-like receptors. Although replication of this finding in other, larger samples is needed, variation in TLR6 may have relevance to the pathogenesis of immunologically mediated diseases.

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Authors and Affiliations

  1. Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, USA

    K Tantisira, R Lazarus, B A Raby, E Silverman & S T Weiss

  2. Arizona Respiratory Center, University of Arizona, Tucson, USA

    W T Klimecki, D Vercelli & F D Martinez

  3. Western Australian Institute for Medical Research, Center for Medical Research, University of Western Australia, Perth, Australia

    L J Palmer

  4. Hematology Division, Brigham and Women's Hospital, Boston, USA

    D J Kwiatkowski

  5. Department of Public Health and Community Medicine, University of Sydney, Australia

    R Lazarus

  6. Harvard Partners Center for Genetics and Genomics, USA

    D J Kwiatkowski & S T Weiss

Authors
  1. K Tantisira
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  2. W T Klimecki
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  3. R Lazarus
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  4. L J Palmer
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  5. B A Raby
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  6. D J Kwiatkowski
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  7. E Silverman
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  8. D Vercelli
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  9. F D Martinez
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  10. S T Weiss
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Corresponding author

Correspondence to K Tantisira.

Additional information

This work was supported by the Program for Genomic Applications, NIH R01: HL66795, Innate Immunity in Heart, Lung and Blood Disease, from the National Heart and Blood Institute, and by NIH 2T32: HL07427-21, The Clinical Epidemiology of Lung Diseases.

Supplementary Information accompanies the paper on Genes and Immunity's website (http://www.nature.com/gene).

Supplementary information

Web Table A

Flanking Sequences of Identified TLR6 SNPs

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Tantisira, K., Klimecki, W., Lazarus, R. et al. Toll-like receptor 6 gene (TLR6): single-nucleotide polymorphism frequencies and preliminary association with the diagnosis of asthma. Genes Immun 5, 343–346 (2004). https://doi.org/10.1038/sj.gene.6364096

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  • DOI: https://doi.org/10.1038/sj.gene.6364096

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