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Genome scan for loci linked to mite sensitivity: the Collaborative Study on the Genetics of Asthma (CSGA)

Abstract

Mite sensitivity has been reported to be a major risk factor for asthma. As part of the Collaborative Study on the Genetics of Asthma (CSGA), a genome scan using mite reactivity (Dermatophagoides Pteronyssinus (Der p) and Dermatophagoides farinae (Der f)) as the phenotype was conducted. In 287 CSGA families, 122 were informative for linkage. Evidence supporting linkage was observed for regions on chromosome 19 (D19S591, lod=2.43, P=0.0008; D19S1037, lod=1.57, P=0.007) and chromosome 20 (D20S473/D20S604, lod=1.41, P=0.01). All three ethnic groups appeared to contribute to the evidence for linkage on chromosome 20. African-American families gave strongest support for linkage on chromosomes 3 (D3S2409, lod=1.33, P=0.01), 12 (D12S373, lod=1.51, P=0.008) and 18 (ATA82B02, lod=1.32, P=0.01). Caucasian families showed strong evidence for linkage on chromosome 19 (D19S591, lod=3.51, P=0.00006). Hispanic families supported linkage on chromosomes 11 (D11S1984, lod=1.56, P=0.007), 13 (D13S787, lod=1.30, P=0.01) and 20 (D20S470, lod=1.71, P=0.005). These results suggest that multiple genes may be involved in controlling skin reactivity to Dermatophoigoies.

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Acknowledgements

This study was supported by the following NIH Grants: U01 HL49612 (JHU), U01 HL49596 and M01 RR00055 (UC), U01 HL59609 and M01 RR00400 (UMN), U01 HL58977, U01 HL49602, U01 HL49609 and M01 RR00600 (University of Maryland and Wake Forest University), HV-48141 (Mammalian Genotyping Service) and HRRC 93-196 (University of New Mexico). In addition to the authors, other coinvestigators and key support personnel for the CSGA includes: Eva Ehrlich, Linda Freidhoff, Rasika Mathias, Beverly Plunkett and Maria Stockton (Johns Hopkins University), Rhonda Peterson, Jennifer Anderson and Heidi Gidley (University of Chicago), Lisa Daniels, Edward Corazalla and Marcia Brott (University of Minnesota), June Pierce, Mark Brown, Adrienne Hill and Cralen Davis (Wake Forest University Data Coordinating Center) and Tim Howard and Jianfeng Xu (Wake Forest University).

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Blumenthal, M., Ober, C., Beaty, T. et al. Genome scan for loci linked to mite sensitivity: the Collaborative Study on the Genetics of Asthma (CSGA). Genes Immun 5, 226–231 (2004). https://doi.org/10.1038/sj.gene.6364063

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