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FcγRIIB gene polymorphisms in Japanese periodontitis patients

Genes & Immunity volume 4, pages 541–546 (2003)Cite this article

Abstract

Human type II low-affinity receptor for immunoglobulin G (FcγRII) constitutes a clustered gene family consisting of FcγRIIA, IIB and IIC genes. FcγRIIB is unique in its ability to transmit inhibitory signals in B cells via immunoreceptor tyrosine-based inhibitory motif (ITIM). B-cell activation and subsequent elevated production of IgG are the immunopathological features of inflammatory disease such as periodontitis. To determine whether an association with periodontitis susceptibility exists, genetic polymorphisms of FcγRIIB were examined in Japanese patients with aggressive periodontitis (AGP) and chronic periodontitis (CP), and in the race-matched healthy controls (HCs). A significant difference was observed in the distribution of FcγRIIB−232I/T allele (exon 5) between the AGP and HC groups, with enrichment of the 232T in the AGP group (P=0.006). In addition, the FcγRIIB-nt 646−184A/G allele (intron 4) distribution was significantly different between the CP and HC groups, with enrichment of the nt 646−184A in the CP group (P=0.011). These results document the association of FcγRIIB gene polymorphisms with susceptibility to periodontitis in the Japanese.

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Acknowledgements

We are grateful to Dr Naoyuki Tsuchiya (Department of Human Genetics, The University of Tokyo) for valuable suggestions, and also to Dr Jun Ohashi (Department of Human Genetics, The University of Tokyo) for statistical guidance. This work was supported by Grant-in-Aids for Scientific Research (12557191, 12672033, 13470461 and 13557189) from the Ministry of Education, Culture, Sports, Science and Technology, Japan, and the fund for Scientific Promotion of Tanaka Industries Co. Ltd, Niigata, Japan.

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Authors and Affiliations

  1. Division of Periodontology, Department of Oral Biological Science, Niigata University, Graduate School of Medical and Dental Sciences, Japan

    K Yasuda, N Sugita, T Kobayashi, K Yamamoto & H Yoshie

  2. General Dentistry and Clinical Education Unit, Niigata University Dental Hospital, Japan

    T Kobayashi

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  1. K Yasuda
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  2. N Sugita
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  5. H Yoshie
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Correspondence to H Yoshie.

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Yasuda, K., Sugita, N., Kobayashi, T. et al. FcγRIIB gene polymorphisms in Japanese periodontitis patients. Genes Immun 4, 541–546 (2003). https://doi.org/10.1038/sj.gene.6364021

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