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IL-1B and IL-6 gene polymorphisms encode significant risk for the development of recurrent aphthous stomatitis (RAS)

Genes & Immunity volume 3, pages 302–305 (2002)Cite this article

Abstract

Recurrent aphthous stomatitis (RAS) is an, ulcerative condition of the mouth, with a polygenic mode of inheritance in which cytokines are thought to play an important role. Ninety-one RAS patients and 91 controls were genotyped for known IL-1A, IL-1B, IL-1RN and IL-6 gene polymorphisms. Inheritance of the G allele of the IL-1B −511 polymorphism was strongly associated with RAS (OR = 2.5, P < 0.00002), with increased numbers of G/G homozygotes (OR = 4.5, P < 0.0005). The G allele of IL-6 −174 also occurred more frequently in RAS (OR = 2.6, P < 0.0001) with greatest risk associated with G/G homozygosity (OR = 3.4, P < 0.0001). IL-1RN VNTR 1/1 homozygotes also occurred more frequently in RAS (OR = 2.0, P < 0.02). Inheritance of the G/G genotype of both IL-1B and IL-6 was a particularly strong predictor for RAS (OR = 8.5).

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Authors and Affiliations

  1. ARC Epidemiology Unit, University of Manchester, Manchester, UK

    M R Bazrafshani, A H Hajeer & W E R Ollier

  2. Department of Dental Diagnostic Sciences, University of Texas Health Sciences Centre, San Antonio, Texas, USA

    M H Thornhill

Authors
  1. M R Bazrafshani
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  2. A H Hajeer
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  3. W E R Ollier
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  4. M H Thornhill
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Correspondence to M H Thornhill.

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Bazrafshani, M., Hajeer, A., Ollier, W. et al. IL-1B and IL-6 gene polymorphisms encode significant risk for the development of recurrent aphthous stomatitis (RAS). Genes Immun 3, 302–305 (2002). https://doi.org/10.1038/sj.gene.6363882

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