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Novel SNPs in a candidate gene, CRTH2, for allergic diseases

Genes & Immunity volume 3, pages 114–116 (2002)Cite this article

Abstract

Sequencing analyses of genomic DNA samples from a Chinese population identified four single-nucleotide polymorphisms (SNPs) of the CRTH2 gene, encoding a chemoattractant receptor predominantly expressed on Th2 cells and a receptor for prostaglandin D2 (PGD2). Two coding-region SNPs with a T to G and a C to A substitutions, resulting in codon changes from Phe to Val and Pro to Thr, respectively. Two additional SNPs were discovered in the 3′ untranslated region (3′-UTR). These newly identified SNPs will be useful for further functional study of variant CRTH2 gene, and for genetic studies of asthma and other immunologic diseases.

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Authors and Affiliations

  1. Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    S-C Hsu, L-C Chen & S-K Huang

  2. Division of Allergy, Department of Pediatrics, Asthma and Rheumatology, Chang Gung Children’s Hospital, Taoyuan, Taiwan, Republic of China, ROC

    L-C Chen, M-L Kuo & J-L Huang

Authors
  1. S-C Hsu
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  2. L-C Chen
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  3. M-L Kuo
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  4. J-L Huang
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  5. S-K Huang
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Corresponding authors

Correspondence to J-L Huang or S-K Huang.

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Hsu, SC., Chen, LC., Kuo, ML. et al. Novel SNPs in a candidate gene, CRTH2, for allergic diseases. Genes Immun 3, 114–116 (2002). https://doi.org/10.1038/sj.gene.6363826

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  • DOI: https://doi.org/10.1038/sj.gene.6363826

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