Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Allele Report
  • Published:

Mannose-binding lectin polymorphisms in a Canary Islands (Spain) population

Genes & Immunity volume 2, pages 292–294 (2001)Cite this article

Abstract

We have compared the structural and promoter variants of the mannose-binding lectin (MBL) gene in a population from Gran Canaria with that from other populations previously reported. The observed frequencies of the seven alleles of the MBL gene in our population were: HYPA, 0.24; LYQA, 0.22; LYPA, 0.08; LXPA, 0.19; LYPB, 0.17; LYQC, 0.03 and HYPD, 0.07. The frequency of non-producer alleles and of MBL-deficient individuals in our population is higher than in other European and Asian population.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Turner MW Mannose-binding lectin in health and disease Immunobiology 1998 199 327–339

    Article  CAS  Google Scholar 

  2. Turner MW, Hamvas RM Mannose-binding lectin: structure, function, genetics and disease associations Rev Immunogenet 2000 2 305–322

    CAS  PubMed  Google Scholar 

  3. Madsen HO, Garred P, Thiel S et al Interplay between promoter and structural gene variants control basal serum levels of Mannan-binding protein J Immunol 1995 155 3013–3020

    CAS  PubMed  Google Scholar 

  4. Madsen HO, Satz ML, Hogh B et al Different molecular events result in low protein levels of Mannan-binding lectin in populations from Southeast Africa and South America J Immunol 1998 161 3169–3175

    CAS  PubMed  Google Scholar 

  5. Davies EJ, Snowden N, Hillarby MC et al Mannose-binding protein gene polymorphism in systemic lupus erythematosus Arthritis Rheum 1995 38 110–114

    Article  CAS  Google Scholar 

  6. Sullivan KE, Wooten C, Goldman D, Petri M Mannose-binding protein genetic polymorphisms in black patients with systemic lupus erythematosus Arthritis Rheum 1996 39 2046–2051

    Article  CAS  Google Scholar 

  7. Horiuchi T, Tsukamoto H, Morita C et al Mannose binding lectin (MBL) gene mutation is not a risk factor for systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in Japanese Genes Immun 2000 1 464–468

    Article  CAS  Google Scholar 

  8. Stanworth SJ, Donn RP, Hassall A et al Absence of an association between mannose-binding lectin polymorphism and rheumatoid arthritis Br J Rheumatol 1998 37 186–188

    Article  CAS  Google Scholar 

  9. Graudal NA, Madsen HO, Tarp U et al The association of variant mannose-binding lectin genotypes with radiographic outcome in rheumatoid arthritis Arthritis Rheum 2000 43 515–521

    Article  CAS  Google Scholar 

  10. Matsushita M, Hijikata M, Matsushita M et al Association of mannose-binding lectin gene haplotype LXPA and LYPB with interferon-resistant hepatitis C virus infection in Japanese patients J Hepatol 1998 29 695–700

    Article  CAS  Google Scholar 

  11. Turner MW, Dinan L, Heatley S et al Restricted polymorphism of the mannose binding lectin gene of indigenous Australians Hum Mol Genet 2000 9 1481–1486

    Article  CAS  Google Scholar 

  12. Blin N, Stafford DW A general method for isolation of high molecular weight DNA from eukaryotes Nucleic Acids Res 1976 3 2303–2308

    Article  CAS  Google Scholar 

  13. Dean AG, Dean JA, Coulombier D et al Epi Info, version 6: a word processing database, and statistics program for epidemiology of microcomputers Centers for Disease Control and Prevention: Atlanta, GA, USA 1994

    Google Scholar 

  14. Excoffier L, Slatkin M Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population Mol Biol Evol 1995 12 921–927

    CAS  Google Scholar 

  15. Pinto F, Cabrera VM, Gonzalez AM et al Human enzyme polymorphism in the Canary Islands. VI. Northwest African influence Human Heredity 1994 44 156–161

    Article  CAS  Google Scholar 

  16. Mead R, Jack D, Pembrey M et al Mannose-binding lectin alleles in a prospectively recruited UK population Lancet 1997 349 1669–1670

    Article  CAS  Google Scholar 

  17. Madsen HO, Videm V, Svejgaard A et al Association of mannose-binding lectin deficiency with severe atherosclerosis Lancet 1998 352 959–960

    Article  CAS  Google Scholar 

  18. Garred P, Harboe M, Oettinger T et al Dual role of mannose-binding protein in infections: another case of heterosis? Eur J Immunogenet 1994 21 125–131

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Immunology, Hospital de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain

    MI García-Laorden, A Manzanedo, F Sánchez-García & C Rodríguez-Gallego

  2. Department of Preventive Medicine, Hospital de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain

    A Figuerola

Authors
  1. MI García-Laorden
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A Manzanedo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A Figuerola
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. F Sánchez-García
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. C Rodríguez-Gallego
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to C Rodríguez-Gallego.

Additional information

This work was supported by a Fondo de Investigaciones Sanitarias (Ministerio de Sanidad) grant (FIS 98/1513).

Rights and permissions

Reprints and permissions

About this article

Cite this article

García-Laorden, M., Manzanedo, A., Figuerola, A. et al. Mannose-binding lectin polymorphisms in a Canary Islands (Spain) population . Genes Immun 2, 292–294 (2001). https://doi.org/10.1038/sj.gene.6363778

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.gene.6363778

Keywords

Search

Advanced search

Quick links