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A genome screen for multiple sclerosis in Italian families

Genes & Immunity volume 2, pages 205–210 (2001)Cite this article

Abstract

We have screened the whole genome for linkage in 40 Italian multiplex families with multiple sclerosis using 322 markers. The GENEHUNTER-PLUS program was used to analyse these data and revealed eight regions of potential linkage where the lod score exceeds the nominal 5% significance level (0.7). No region of linkage with genome-wide significance was identified and none of the markers showed evidence of statistically significant transmission disequilibrium. Overall these results have refined the linkage data relating to this disease in Italians modestly supporting some previously identified areas of interest and helping to exclude others.

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Authors and Affiliations

  1. University of Cambridge Neurology Unit, Addenbrooke’s Hospital, Hills Road, Cambridge, 2QQ CB2, UK

    S Broadley, S Sawcer, A Hensiek, F Coraddu, J Gray, R Roxburgh & A Compston

  2. Department of Medical Sciences, Chair of Human Genetics, University of Piemonte Orientale ‘A. Avogadro’, Novara, Italy

    S D’Alfonso

  3. MRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge, CB2 2SR, UK

    D Clayton

  4. Department of Neurological Sciences, University “La Sapienza”, Rome, Italy

    C Buttinelli

  5. Department of Medical Sciences, University of Catanzaro and Institute of Experimental Medicine and Biotechnology, CNR, Italy

    A Quattrone

  6. Department of Neurological and Psychiatric Sciences, University of Bari, Italy

    M Trojano

  7. Department of Neurological and Psychiatric Sciences, University of Florence, Italy

    L Massacesi

Authors
  1. S Broadley
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  2. S Sawcer
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  3. S D’Alfonso
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  4. A Hensiek
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  5. F Coraddu
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  6. J Gray
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  7. R Roxburgh
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  8. D Clayton
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  9. C Buttinelli
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  10. A Quattrone
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  11. M Trojano
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  12. L Massacesi
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  13. A Compston
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Corresponding author

Correspondence to L Massacesi.

Additional information

This work was supported by the Multiple Sclerosis Society of Great Britain and Ireland, the Medical Research Council, the Wellcome Trust, the Italian Multiple Sclerosis Foundation (FISM), the National Project on Multiple Sclerosis of the Istituto Superiore di Sanità and by the Italian Ministry of University Scientific Research and Technology.

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Broadley, S., Sawcer, S., D’Alfonso, S. et al. A genome screen for multiple sclerosis in Italian families . Genes Immun 2, 205–210 (2001). https://doi.org/10.1038/sj.gene.6363758

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  • DOI: https://doi.org/10.1038/sj.gene.6363758

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