Amyotrophic lateral sclerosis

Credit: Mark Smith

It begins with small symptoms such as muscle twitches or weakness. Eventually, amyotrophic lateral sclerosis (ALS) robs a person of all muscle control, resulting in paralysis, the inability to speak and, inevitably, death.

The cause of ALS (also known as motor neuron disease or MND) is unknown. Genes linked to the disease have been identified, including one (C9ORF72) that seems to be particularly important (see page S106). Lifestyle and environmental factors also seem to influence ALS (S109). But researchers should be wary about too much of a focus on either genetics or the environment; both can work together to bring on the disease (S112).

Despite high-profile cases such as baseball player Lou Gehrig and physicist Stephen Hawking, ALS was long considered an obscure disease. In 2014, however, the Ice Bucket Challenge fundraiser brought it to public attention — albeit briefly. Research supported by ice-bucket money is starting to pay off, but such fundraising is hard to repeat (S113).

Treatments for ALS are limited, but new drugs are starting to be approved and stem-cell therapy and gene therapy will soon be coming into their own (see S120). And technology is devising new ways for doctors to diagnose cases, monitor progression and get patients into clinical trials (S115). Many such trials are under way, and they are spurring cautious optimism about treatments for this devastating illness (S118).

Many patients try unproven alternative therapies. Far from dismissing them, physicians and researchers can help patients check the safety and possible benefit of such therapies (S122).

We are pleased to acknowledge the financial support of Biogen, BrainStorm Cell Therapeutics, and Cytokinetics in producing this Outlook. Additional funding was provided by a grant from Mitsubishi Tanabe Pharma America, Inc. As always, Nature has sole responsibility for all editorial content.

This article is part of Nature Outlook: Amyotrophic lateral sclerosis, an editorially independent supplement produced with the financial support of third parties. About this content.

Author information

Affiliations

Authors

Related links

Related links

Related links in Nature Research

ALS subject page

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Owens, B. Amyotrophic lateral sclerosis. Nature 550, S105 (2017). https://doi.org/10.1038/550S105a

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Sign up for the Nature Briefing newsletter for a daily update on COVID-19 science.
Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing