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In Retrospect

The inflammasome turns 15

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The discovery of the inflammasome protein complex in 2002 was a breakthrough in our understanding of how the immune system triggers inflammation. Now researchers are attempting to modulate its activity to treat disease.

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Figure 1: The inflammasome.

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References

  1. Martinon, F., Burns, K. & Tschopp, J. Mol. Cell 10, 417–426 (2002).

    CAS  Article  Google Scholar 

  2. Lamkanfi, M. & Dixit, V. M. Cell 157, 1013–1022 (2014).

    CAS  Article  Google Scholar 

  3. Man, S. M. & Kanneganti, T. D. Nature Rev. Immunol. 16, 7–21 (2016).

    CAS  Article  Google Scholar 

  4. Kayagaki, N. et al. Nature 479, 117–121 (2011).

    ADS  CAS  Article  Google Scholar 

  5. Thornberry, N. A. et al. Nature 356, 768–774 (1992).

    ADS  CAS  Article  Google Scholar 

  6. Cerretti, D. P. et al. Science 256, 97–100 (1992).

    ADS  CAS  Article  Google Scholar 

  7. Gu, Y. et al. Science 275, 206–209 (1997).

    CAS  Article  Google Scholar 

  8. Ghayur, T. et al. Nature 386, 619–623 (1997).

    ADS  CAS  Article  Google Scholar 

  9. Monack, D. M., Raupach, B., Hromockyj, A. E. & Falkow, S. Proc. Natl Acad. Sci. USA 93, 9833–9838 (1996).

    ADS  CAS  Article  Google Scholar 

  10. Chen, Y., Smith, M. R., Thirumalai, K. & Zychlinsky, A. EMBO J. 15, 3853–3860 (1996).

    CAS  Article  Google Scholar 

  11. Hersh, D. et al. Proc. Natl Acad. Sci. USA 96, 2396–2401 (1999).

    ADS  CAS  Article  Google Scholar 

  12. Lamkanfi, M. et al. J. Immunol. 185, 4385–4392 (2010).

    CAS  Article  Google Scholar 

  13. Groß, O. et al. Immunity 36, 388–400 (2012).

    Article  Google Scholar 

  14. Kayagaki, N. et al. Nature 526, 666–671 (2015).

    ADS  CAS  Article  Google Scholar 

  15. Shi, J. et al. Nature 526, 660–665 (2015).

    ADS  CAS  Article  Google Scholar 

  16. He, W. T. et al. Cell Res. 25, 1285–1298 (2015).

    CAS  Article  Google Scholar 

  17. Mamantopoulos, M. et al. Immunity 47, 339–348 (2017).

    Google Scholar 

  18. Ridker, P. M., Thuren, T., Zalewski, A. & Libby, P. Am. Heart J. 162, 597–605 (2011).

    CAS  Article  Google Scholar 

  19. Ridker, P. M. et al. N. Engl. J. Med. http://dx.doi.org/10.1056/NEJMoa1707914 (2017).

  20. Lamkanfi, M. et al. J. Cell Biol. 187, 61–70 (2009).

    CAS  Article  Google Scholar 

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Correspondence to Mohamed Lamkanfi or Vishva M. Dixit.

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Lamkanfi, M., Dixit, V. The inflammasome turns 15. Nature 548, 534–535 (2017). https://doi.org/10.1038/548534a

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