Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

In Retrospect

The inflammasome turns 15


The discovery of the inflammasome protein complex in 2002 was a breakthrough in our understanding of how the immune system triggers inflammation. Now researchers are attempting to modulate its activity to treat disease.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The inflammasome.


  1. See all news & views


  1. Martinon, F., Burns, K. & Tschopp, J. Mol. Cell 10, 417–426 (2002).

    Article  CAS  Google Scholar 

  2. Lamkanfi, M. & Dixit, V. M. Cell 157, 1013–1022 (2014).

    Article  CAS  Google Scholar 

  3. Man, S. M. & Kanneganti, T. D. Nature Rev. Immunol. 16, 7–21 (2016).

    Article  CAS  Google Scholar 

  4. Kayagaki, N. et al. Nature 479, 117–121 (2011).

    Article  ADS  CAS  Google Scholar 

  5. Thornberry, N. A. et al. Nature 356, 768–774 (1992).

    Article  ADS  CAS  Google Scholar 

  6. Cerretti, D. P. et al. Science 256, 97–100 (1992).

    Article  ADS  CAS  Google Scholar 

  7. Gu, Y. et al. Science 275, 206–209 (1997).

    Article  CAS  Google Scholar 

  8. Ghayur, T. et al. Nature 386, 619–623 (1997).

    Article  ADS  CAS  Google Scholar 

  9. Monack, D. M., Raupach, B., Hromockyj, A. E. & Falkow, S. Proc. Natl Acad. Sci. USA 93, 9833–9838 (1996).

    Article  ADS  CAS  Google Scholar 

  10. Chen, Y., Smith, M. R., Thirumalai, K. & Zychlinsky, A. EMBO J. 15, 3853–3860 (1996).

    Article  CAS  Google Scholar 

  11. Hersh, D. et al. Proc. Natl Acad. Sci. USA 96, 2396–2401 (1999).

    Article  ADS  CAS  Google Scholar 

  12. Lamkanfi, M. et al. J. Immunol. 185, 4385–4392 (2010).

    Article  CAS  Google Scholar 

  13. Groß, O. et al. Immunity 36, 388–400 (2012).

    Article  Google Scholar 

  14. Kayagaki, N. et al. Nature 526, 666–671 (2015).

    Article  ADS  CAS  Google Scholar 

  15. Shi, J. et al. Nature 526, 660–665 (2015).

    Article  ADS  CAS  Google Scholar 

  16. He, W. T. et al. Cell Res. 25, 1285–1298 (2015).

    Article  CAS  Google Scholar 

  17. Mamantopoulos, M. et al. Immunity 47, 339–348 (2017).

    Google Scholar 

  18. Ridker, P. M., Thuren, T., Zalewski, A. & Libby, P. Am. Heart J. 162, 597–605 (2011).

    Article  CAS  Google Scholar 

  19. Ridker, P. M. et al. N. Engl. J. Med. (2017).

  20. Lamkanfi, M. et al. J. Cell Biol. 187, 61–70 (2009).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding authors

Correspondence to Mohamed Lamkanfi or Vishva M. Dixit.

Related links

Related links

Related links in Nature Research

Immunology: Gut sensor halts viral attack

Immunology: Caspase target drives pyroptosis

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lamkanfi, M., Dixit, V. The inflammasome turns 15. Nature 548, 534–535 (2017).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing