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Therapeutics

Click and discover

Details of the activity of promising anticancer drugs known as BET inhibitors remain elusive. An approach called click chemistry enables in-depth analysis of how these drugs modulate the function of a crucial target protein, BRD4.

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Figure 1: Click chemistry for preclinical drug evaluation.

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Correspondence to George S. Vassiliou or Shankar Balasubramanian.

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Vassiliou, G., Balasubramanian, S. Click and discover. Nature 548, 162–164 (2017). https://doi.org/10.1038/548162a

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