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In Retrospect

A decade of shared genomic associations

A paper that analysed genetic variants in 14,000 people to identify disease-associated regions set the standard for collaborative genome-wide association studies and provided methodological advances whose effects are still felt today.

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Figure 1: Ever-increasing sample sizes for genome-wide association studies (GWAS).

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References

  1. The Wellcome Trust Case Control Consortium. Nature 447, 661–678 (2007).

  2. Hirschhorn, J. N., Lohmueller, K., Byrne, E. & Hirschhorn, K. Genet. Med. 4, 45–61 (2002).

    Article  CAS  Google Scholar 

  3. Klein, R. J. et al. Science 308, 385–389 (2005).

    Article  ADS  CAS  Google Scholar 

  4. Hindorff, L. A. et al. Proc. Natl Acad. Sci. USA 106, 9362–9367 (2009).

    Article  ADS  CAS  Google Scholar 

  5. Manolio, T. A., Brooks, L. D. & Collins, F. C. J. Clin. Invest. 118, 1590–1605 (2008).

    Article  CAS  Google Scholar 

  6. Mossman, K. Sci. Am. 298, 42 (2008).

    ADS  Google Scholar 

  7. Summerskill, W. Lancet 371, 370–371 (2008).

    Article  Google Scholar 

  8. Warren, H. R. et al. Nature Genet. 49, 403–415 (2017).

    Article  CAS  Google Scholar 

  9. Marchini, J., Howie, B., Myers, S., McVean, G. & Donnelly, P. Nature Genet. 39, 906–913 (2007).

    Article  CAS  Google Scholar 

  10. Homer, N. et al. PLoS Genet. 4, e1000167 (2008).

    Article  Google Scholar 

  11. Popejoy, A. B. & Fullerton, S. M. Nature 538, 161–164 (2016).

    Article  ADS  CAS  Google Scholar 

  12. Evans, D. S. et al. Hum. Mol. Genet. 25, 4350–4368 (2016).

    Article  CAS  Google Scholar 

  13. Cade, B. E. et al. Am. J. Respir. Crit. Care Med. 194, 886–897 (2016).

    Article  Google Scholar 

  14. Chan, S. L., Jin, S., Loh, M. & Brunham, L. R. Pharmacogenomics 16, 1161–1178 (2015).

    Article  CAS  Google Scholar 

  15. Price, A. L., Spencer, C. C. A. & Donnelly, P. Proc. R. Soc. B 282, 20151684 (2015).

    Article  Google Scholar 

Download references

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Correspondence to Teri A. Manolio.

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Manolio, T. A decade of shared genomic associations. Nature 546, 360–361 (2017). https://doi.org/10.1038/546360a

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