Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Diversity breeds tolerance

A gene has been identified that underpins the capacity of mycobacterial cells to divide to produce physiologically different daughter cells. This finding has implications for drug treatment of tuberculosis. See Letter p.153

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Heterogeneity in bacterial-cell populations.


  1. See all news & views


  1. World Health Organization. Global Tuberculosis Report 2016 (World Health Organization, 2016).

  2. Rego, E. H., Audette, R. E. & Rubin, E. J. Nature 546, 153–157 (2017).

    ADS  CAS  Article  Google Scholar 

  3. Kester, J. C. & Fortune, S. M. Crit. Rev. Biochem. Mol. Biol. 49, 91–101 (2014).

    CAS  Article  Google Scholar 

  4. Verstraeten, N., Knapen, W., Fauvart, M. & Michiels, J. Methods Mol. Biol. 1333, 3–13 (2016).

    CAS  Article  Google Scholar 

  5. Aldridge, B. B. et al. Science 335, 100–104 (2012).

    ADS  CAS  Article  Google Scholar 

  6. Maglica, Ž., Özdemir, E. & McKinney, J. D. MBio 6, e02236–14 (2015).

    CAS  Article  Google Scholar 

  7. Manina, G., Dhar, N. & McKinney, J. D. Cell Host Microbe 17, 32–46 (2015).

    CAS  Article  Google Scholar 

  8. Liu, Y. et al. J. Exp. Med. 213, 809–825 (2016).

    CAS  Article  Google Scholar 

  9. Levin-Reisman, I. et al. Science 355, 826–830 (2017).

    ADS  CAS  Article  Google Scholar 

  10. Zheng, H. et al. Nature Chem. Biol. 13, 218–225 (2017).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to David G. Russell.

Related links

Related links

Related links in Nature Research

Microbiology: The bacterial cell wall takes centre stage

Microbiology: Bacterial transmission tactics

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Russell, D. Diversity breeds tolerance. Nature 546, 44–45 (2017).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing