Individuals who lack a functional copy of a gene — gene knockouts — can reveal the gene's role. Most knockout research has used model organisms, but now a comprehensive catalogue of human knockouts is in sight. See Letter p.235
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Plenge, R. Human genes lost and their functions found. Nature 544, 171–172 (2017). https://doi.org/10.1038/544171a
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DOI: https://doi.org/10.1038/544171a
