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Cancer therapy

The leukaemia epigenome targeted

Modification of methyl groups attached to DNA alters gene expression, and mutations that deregulate this methylation are common in some leukaemias. Drugs that target aberrant methylation are emerging as promising therapeutics.

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Figure 1: The yin and yang of mutant IDH and TET2 proteins.

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Correspondence to Julie-Aurore Losman.

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Losman, JA. The leukaemia epigenome targeted. Nature 543, 634–635 (2017). https://doi.org/10.1038/543634a

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