Modification of methyl groups attached to DNA alters gene expression, and mutations that deregulate this methylation are common in some leukaemias. Drugs that target aberrant methylation are emerging as promising therapeutics.
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Losman, JA. The leukaemia epigenome targeted. Nature 543, 634–635 (2017). https://doi.org/10.1038/543634a
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DOI: https://doi.org/10.1038/543634a
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Precision therapy for acute myeloid leukemia
Journal of Hematology & Oncology (2018)
