Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

In Retrospect

Forty years of cellular clues from worms

Nature volume 543, pages 628–630 (2017)Cite this article

Subjects

The cell divisions that occur when a larva develops into an adult Caenorhabditis elegans worm were described in a cell-lineage map in 1977. The work has provided the foundation for many discoveries about developmental mechanisms.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Understanding development at a cellular level in the worm Caenorhabditis elegans.

Notes

  1. See all news & views

References

  1. Sulston, J. E. & Horvitz, H. R. Dev. Biol. 56, 110–156 (1977).

    Article  CAS  Google Scholar 

  2. Kimble, J. & Hirsh, D. Dev. Biol. 70, 396–417 (1979).

    Article  CAS  Google Scholar 

  3. Sulston, J. E., Albertson, D. G. & Thomson, J. N. Dev. Biol. 78, 542–576 (1980).

    Article  CAS  Google Scholar 

  4. Sammut, M. et al. Nature 526, 385–390 (2015).

    Article  CAS  ADS  Google Scholar 

  5. Chalfie, M., Horvitz, H. R. & Sulston, J. E. Cell 24, 59–69 (1981).

    Article  CAS  Google Scholar 

  6. Greenwald, I. S., Sternberg, P. W. & Horvitz, H. R. Cell 34, 435–444 (1983).

    Article  CAS  Google Scholar 

  7. Ambros, V. & Horvitz, H. R. Science 26, 409–416 (1984).

    Article  ADS  Google Scholar 

  8. Lee, R. C., Feinbaum, R. L. & Ambros, V. Cell 75, 843–854 (1993).

    Article  CAS  Google Scholar 

  9. Kenyon, C. Cell 46, 477–487 (1986).

    Article  CAS  Google Scholar 

  10. Sternberg, P. W. & Horvitz, H. R. Dev. Biol. 130, 67–73 (1988).

    Article  CAS  Google Scholar 

  11. Horvitz, H. R. & Sternberg, P. W. Nature 351, 535–541 (1991).

    Article  CAS  ADS  Google Scholar 

  12. Sulston, J. E. & White, J. G. Dev. Biol. 78, 577–597 (1980).

    Article  CAS  Google Scholar 

  13. Kimble, J. Dev. Biol. 87, 286–300 (1981).

    Article  CAS  Google Scholar 

  14. Sawa, H., Lobel, L. & Horvitz, H. R. Genes Dev. 10, 2189–2197 (1996).

    Article  CAS  Google Scholar 

  15. Lin, R., Hill, R. J. & Priess, J. R. Cell 92, 229–239 (1998).

    Article  CAS  Google Scholar 

  16. Zacharias, A. L., Walton, T., Preston, E. & Murray, J. I. PLoS Genet. 11, e1005585 (2015).

    Article  Google Scholar 

  17. The C. elegans Sequencing Consortium. Science 282, 2012–2018 (1998).

  18. Schwarz, E. M., Kato, M. & Sternberg, P. W. Proc. Natl Acad. Sci. USA 109, 16246–16251 (2012).

    Article  CAS  ADS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Paul W. Sternberg is in the Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, USA.,

    Paul W. Sternberg

Authors
  1. Paul W. Sternberg
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Paul W. Sternberg.

Related links

Related links

Related links in Nature Research

Systems biology: Molecular memoirs of a cellular family

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sternberg, P. Forty years of cellular clues from worms. Nature 543, 628–630 (2017). https://doi.org/10.1038/543628a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/543628a

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing