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Non-coding RNA

More uses for genomic junk

It emerges that nascent non-coding RNAs transcribed from regulatory DNA sequences called enhancers bind to the enzyme CBP to promote its activity locally. In turn, the activities of CBP stimulate further enhancer transcription.

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Figure 1: Enhancer RNA modulates gene expression.


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Correspondence to Karen Adelman.

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Transcription: Enhancers make non-coding RNA

Gene regulation: Long RNAs wire up cancer growth

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Adelman, K., Egan, E. More uses for genomic junk. Nature 543, 183–185 (2017).

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