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Molecular biology

RNA editing packs a one-two punch

Optimal protein synthesis requires bases in transfer RNAs to be modified. A key modification has been shown to involve an unusual two-step mechanism that entails the sequential activities of two enzymes. See Letter p.494

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Figure 1: Two-step mechanism for RNA editing.


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  1. Farajollahi, S. & Maas, S. Trends Genet. 26, 221–230 (2010).

    Article  CAS  Google Scholar 

  2. Benne, R. et al. Cell 46, 819–826 (1986).

    Article  CAS  Google Scholar 

  3. Rubio, M. A. T. et al. Nature 542, 494–497 (2017).

    Article  ADS  CAS  Google Scholar 

  4. Grosjean, H. et al. Biochimie 78, 488–501 (1996).

    Article  CAS  Google Scholar 

  5. Lonergan, K. M. & Gray, M. W. Science 259, 812–816 (1993).

    Article  ADS  CAS  Google Scholar 

  6. Gerber, A. P. & Keller, W. Science 286, 1146–1149 (1999).

    Article  CAS  Google Scholar 

  7. Randau, L. et al. Science 324, 657–659 (2009).

    Article  ADS  CAS  Google Scholar 

  8. Rubio, M. A. et al. Proc. Natl Acad. Sci. USA 104, 7821–7826 (2007).

    Article  ADS  CAS  Google Scholar 

  9. Jühling, F. et al. Nucleic Acids Res. 37, D159–D162 (2009).

    Article  Google Scholar 

  10. Fleming, I. M. et al. Sci. Rep. 6, 21438 (2016).

    Article  ADS  CAS  Google Scholar 

  11. Conticello, S. G., Langlois, M. A., Yang, Z. & Neuberger, M. S. Adv. Immunol. 94, 37–73 (2007).

    Article  CAS  Google Scholar 

  12. Savva, Y. A., Rezaei A., St Laurent, G. & Reenan, R. A. Front. Genet. 7, 100 (2016).

    Article  Google Scholar 

  13. Li, J. B. et al. Science 324, 1210–1213 (2009).

    Article  ADS  CAS  Google Scholar 

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Correspondence to William T. Yewdell or Jayanta Chaudhuri.

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Yewdell, W., Chaudhuri, J. RNA editing packs a one-two punch. Nature 542, 420–421 (2017).

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